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- W2000628133 abstract "We have isolated recombinant λ-phage clones that contain sequences complementary to the 3′ half of the cDNA encoding human topoisomerase I (hTOP1). These λ clones belong to three distinct classes: class-I clones contain sequences from the active gene located on human chromosome 20. Class-II and class-III clones contain sequences corresponding to the cDNA encoding hTOP1 from nucleotide (nt) 2208 to 3434 and from nt 1639 to 3434, respectively. These sequences exhibit the characteristics features of retroposons or retrosequences. They are most likely derived from truncated mRNA transcripts of the active gene. We propose to designate the truncated hTOP1 sequence located on chromosome 1 as the pseudogene 1 (ψ1-hTOP1) and the sequence on chromosome 22 as the pseudogene 2 (ψ2-hTOP1). Pseudogene ψ1-hTOP1 has two unique properties: it is flanked by upstream sequences which display promoter activity in transient expression assays, and it contains an open reading frame which could code for the 211 C-terminal amino acids of hTOP1. Pseudogene ψ2h-TOP1 is located within an AluI repetitive element and is flanked on one side by a (CA)21 stretch." @default.
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- W2000628133 date "1990-07-01" @default.
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- W2000628133 title "Molecular structures of two human DNA topoisomerase I retrosequences" @default.
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- W2000628133 doi "https://doi.org/10.1016/0378-1119(90)90095-9" @default.
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