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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000628284> ?p ?o ?g. }

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• W2000628284 abstract "The NF-κB/Rel family member c-Rel was described to be required for the development of TH1 responses. However, the role of c-Rel in the differentiation of TH17 and regulatory CD4+Foxp3+ T cells (Treg) remains obscure. Here, we show that in the absence of c-Rel, in vitro differentiation of pro-inflammatory TH17 cells is normal. In contrast, generation of inducible Treg (iTreg) within c-Rel-deficient CD4+ T cells was severely hampered and correlated to reduced numbers of Foxp3+ T cells in vivo. Mechanistically, in vitro conversion of naive CD4+ T cells into iTreg was crucially dependent on c-Rel-mediated synthesis of endogenous IL-2. The addition of exogenous IL-2 was sufficient to rescue the development of c-Rel-deficient iTreg. Thus, c-Rel is essential for the development of Foxp3+ Treg but not for TH17 cells via regulating the production of IL-2." @default.
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• W2000628284 date "2010-03-01" @default.
• W2000628284 modified "2023-10-18" @default.
• W2000628284 title "c-Rel is crucial for the induction of Foxp3⁺regulatory CD4⁺T cells but not T_H17 cells" @default.
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• W2000628284 doi "https://doi.org/10.1002/eji.200940260" @default.
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