Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000629897> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2000629897 endingPage "98" @default.
- W2000629897 startingPage "85" @default.
- W2000629897 abstract "The term kindling refers to the phenomenon whereby repeated administration of an initially subconvulsive electrical stimulus results in progressive intensification of stimulus-induced epileptic activity, culminating in a generalized seizure. Once established, this enhanced sensitivity to electrical stimulation (i.e., kindling effect) is permanent. Pharmacologic studies indicate that the interaction of acetylcholine with brain muscarinic receptors may contribute to two important events in kindling: (i) the development of the permanent enhanced sensitivity to electrical stimulation by which kindling is defined; and (ii) suppression of spontaneous interictal spiking. The present report confirmed and extended our previous findings by demonstrating that the muscarinic cholinergic receptor declines involved not only the stimulated amygdala, but also both hippocampal formations of kindled rats. The decline of muscarinic receptors within the hippocampal formations involved mainly the dentate gyri and spares the CA1 regions. Correlative electrophysiologic and biochemical studies did not confirm a relationship between spontaneous interictal spiking and the receptor declines in kindling. The spiking and seizures induced by the convulsant agent, pentylenetetrazol, failed to induce a receptor decline. The results imply that the receptor declines of the kindled animals are related to some property of the kindling per se. In light of the propensity of hippocampal circuitry to develop long-term potentiation, the biochemical evidence of hippocampal involvement in amygdala kindling is intriguing." @default.
- W2000629897 created "2016-06-24" @default.
- W2000629897 creator A5023001769 @default.
- W2000629897 creator A5068814653 @default.
- W2000629897 creator A5070835383 @default.
- W2000629897 date "1980-07-01" @default.
- W2000629897 modified "2023-09-23" @default.
- W2000629897 title "Amygdala kindling induces muscarinic cholinergic receptor declines in a highly specific distribution within the limbic system" @default.
- W2000629897 cites W1963617392 @default.
- W2000629897 cites W1983649348 @default.
- W2000629897 cites W1988228223 @default.
- W2000629897 cites W1994983905 @default.
- W2000629897 cites W2000979372 @default.
- W2000629897 cites W2009782005 @default.
- W2000629897 cites W2018217028 @default.
- W2000629897 cites W2019884656 @default.
- W2000629897 cites W2022958944 @default.
- W2000629897 cites W2028727145 @default.
- W2000629897 cites W2032451360 @default.
- W2000629897 cites W2042714538 @default.
- W2000629897 cites W2072281981 @default.
- W2000629897 cites W2076644208 @default.
- W2000629897 cites W2086995946 @default.
- W2000629897 cites W2094257560 @default.
- W2000629897 cites W2103946141 @default.
- W2000629897 cites W2432314848 @default.
- W2000629897 doi "https://doi.org/10.1016/0014-4886(80)90145-4" @default.
- W2000629897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7389852" @default.
- W2000629897 hasPublicationYear "1980" @default.
- W2000629897 type Work @default.
- W2000629897 sameAs 2000629897 @default.
- W2000629897 citedByCount "67" @default.
- W2000629897 crossrefType "journal-article" @default.
- W2000629897 hasAuthorship W2000629897A5023001769 @default.
- W2000629897 hasAuthorship W2000629897A5068814653 @default.
- W2000629897 hasAuthorship W2000629897A5070835383 @default.
- W2000629897 hasConcept C100691959 @default.
- W2000629897 hasConcept C126322002 @default.
- W2000629897 hasConcept C169760540 @default.
- W2000629897 hasConcept C170493617 @default.
- W2000629897 hasConcept C185592680 @default.
- W2000629897 hasConcept C207723603 @default.
- W2000629897 hasConcept C22885893 @default.
- W2000629897 hasConcept C2778186239 @default.
- W2000629897 hasConcept C2779144063 @default.
- W2000629897 hasConcept C33789571 @default.
- W2000629897 hasConcept C529278444 @default.
- W2000629897 hasConcept C541082541 @default.
- W2000629897 hasConcept C64123433 @default.
- W2000629897 hasConcept C71924100 @default.
- W2000629897 hasConcept C86803240 @default.
- W2000629897 hasConceptScore W2000629897C100691959 @default.
- W2000629897 hasConceptScore W2000629897C126322002 @default.
- W2000629897 hasConceptScore W2000629897C169760540 @default.
- W2000629897 hasConceptScore W2000629897C170493617 @default.
- W2000629897 hasConceptScore W2000629897C185592680 @default.
- W2000629897 hasConceptScore W2000629897C207723603 @default.
- W2000629897 hasConceptScore W2000629897C22885893 @default.
- W2000629897 hasConceptScore W2000629897C2778186239 @default.
- W2000629897 hasConceptScore W2000629897C2779144063 @default.
- W2000629897 hasConceptScore W2000629897C33789571 @default.
- W2000629897 hasConceptScore W2000629897C529278444 @default.
- W2000629897 hasConceptScore W2000629897C541082541 @default.
- W2000629897 hasConceptScore W2000629897C64123433 @default.
- W2000629897 hasConceptScore W2000629897C71924100 @default.
- W2000629897 hasConceptScore W2000629897C86803240 @default.
- W2000629897 hasIssue "1" @default.
- W2000629897 hasLocation W20006298971 @default.
- W2000629897 hasLocation W20006298972 @default.
- W2000629897 hasOpenAccess W2000629897 @default.
- W2000629897 hasPrimaryLocation W20006298971 @default.
- W2000629897 hasRelatedWork W1934459747 @default.
- W2000629897 hasRelatedWork W1943327045 @default.
- W2000629897 hasRelatedWork W1964944774 @default.
- W2000629897 hasRelatedWork W1988412833 @default.
- W2000629897 hasRelatedWork W2032451360 @default.
- W2000629897 hasRelatedWork W2093915975 @default.
- W2000629897 hasRelatedWork W2424466730 @default.
- W2000629897 hasRelatedWork W4290683977 @default.
- W2000629897 hasRelatedWork W66687320 @default.
- W2000629897 hasRelatedWork W112938447 @default.
- W2000629897 hasVolume "69" @default.
- W2000629897 isParatext "false" @default.
- W2000629897 isRetracted "false" @default.
- W2000629897 magId "2000629897" @default.
- W2000629897 workType "article" @default.