FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000632124> ?p ?o ?g. }

• W2000632124 abstract "Fosfluconazole is a phosphate pro-drug of fluconazole (FLCZ). This study was conducted to determine the pharmacokinetics of fosfluconazole and FLCZ following a single intravenous injection of fosfluconazole in subjects with hepatic impairment and to compare them with healthy subjects.Twenty-four subjects (12 with normal hepatic function and 12 with chronic stable mild to moderate impaired hepatic function) received a single 1000-mg bolus intravenous injection of fosfluconazole. Concentrations of fosfluconazole and FLCZ were determined in plasma and urine samples taken up to 192 h and 48 h postdose, respectively.The total clearance of fosfluconazole was higher and the t(1/2,Z) and mean residence time were shorter in hepatically impaired subjects than in normal subjects. This may reflect more rapid conversion to FLCZ. The degree of protein binding of fosfluconazole (> 90%) and the amount of fosfluconazole excreted in the urine were similar in both groups. Slightly higher mean plasma concentrations of FLCZ were observed in the impaired group than in the normal group; however, hepatic impairment had no statistically significant effect on the FLCZ pharmacokinetic parameters apart from t(max). The t(max) values were 4.8 h and 3.1 h in the normal and impaired subjects, respectively. The shorter t(max) for FLCZ is also consistent with the more rapid conversion in the impaired subjects. The ratios (95% confidence intervals) for C(max) and AUC of FLCZ (impaired/normal) were 106.0% (92.8, 121.2) and 115.6% (86.4, 154.7), respectively. There were no serious adverse events, and no discontinuations due to adverse events or laboratory test abnormalities. The adverse events reported were mostly mild in severity and no trend could be discerned between the groups.Fosfluconazole was more rapidly converted to FLCZ in the hepatically impaired subjects but the FLCZ pharmacokinetic parameters (except t(max)) were not statistically significantly affected by hepatic impairment. Fosfluconazole was well tolerated by both groups. These results suggest that there is no requirement to adjust the dose of fosfluconazole when administered to subjects with mild to moderate hepatic impairment." @default.
• W2000632124 created "2016-06-24" @default.
• W2000632124 creator A5003495360 @default.
• W2000632124 creator A5022097262 @default.
• W2000632124 creator A5051240494 @default.
• W2000632124 date "2005-02-01" @default.
• W2000632124 modified "2023-09-27" @default.
• W2000632124 title "The effects of hepatic impairment on the pharmacokinetics of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole" @default.
• W2000632124 cites W122224149 @default.
• W2000632124 cites W123814410 @default.
• W2000632124 cites W1550111394 @default.
• W2000632124 cites W1566286674 @default.
• W2000632124 cites W1902685497 @default.
• W2000632124 cites W1967559354 @default.
• W2000632124 cites W1977736314 @default.
• W2000632124 cites W1983798558 @default.
• W2000632124 cites W1986813862 @default.
• W2000632124 cites W1988775742 @default.
• W2000632124 cites W1997327742 @default.
• W2000632124 cites W2000632124 @default.
• W2000632124 cites W2017253392 @default.
• W2000632124 cites W2018445998 @default.
• W2000632124 cites W2025102763 @default.
• W2000632124 cites W2031731820 @default.
• W2000632124 cites W2038411118 @default.
• W2000632124 cites W2046428639 @default.
• W2000632124 cites W2046808955 @default.
• W2000632124 cites W2050733782 @default.
• W2000632124 cites W2057217749 @default.
• W2000632124 cites W2060123467 @default.
• W2000632124 cites W2072182656 @default.
• W2000632124 cites W2076052242 @default.
• W2000632124 cites W2086229992 @default.
• W2000632124 cites W2094616030 @default.
• W2000632124 cites W2117917197 @default.
• W2000632124 cites W2124404610 @default.
• W2000632124 cites W2135234012 @default.
• W2000632124 cites W2140578325 @default.
• W2000632124 cites W2143449612 @default.
• W2000632124 cites W2317790888 @default.
• W2000632124 cites W2402545572 @default.
• W2000632124 cites W2408275512 @default.
• W2000632124 cites W2414198523 @default.
• W2000632124 cites W25578169 @default.
• W2000632124 cites W2591717879 @default.
• W2000632124 cites W360837428 @default.
• W2000632124 cites W4254354819 @default.
• W2000632124 cites W53558209 @default.
• W2000632124 doi "https://doi.org/10.1111/j.1365-2125.2004.02234.x" @default.
• W2000632124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1884746" @default.
• W2000632124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15676037" @default.
• W2000632124 hasPublicationYear "2005" @default.
• W2000632124 type Work @default.
• W2000632124 sameAs 2000632124 @default.
• W2000632124 citedByCount "16" @default.
• W2000632124 countsByYear W20006321242012 @default.
• W2000632124 countsByYear W20006321242016 @default.
• W2000632124 countsByYear W20006321242017 @default.
• W2000632124 countsByYear W20006321242018 @default.
• W2000632124 countsByYear W20006321242019 @default.
• W2000632124 countsByYear W20006321242020 @default.
• W2000632124 crossrefType "journal-article" @default.
• W2000632124 hasAuthorship W2000632124A5003495360 @default.
• W2000632124 hasAuthorship W2000632124A5022097262 @default.
• W2000632124 hasAuthorship W2000632124A5051240494 @default.
• W2000632124 hasBestOaLocation W20006321242 @default.
• W2000632124 hasConcept C108215921 @default.
• W2000632124 hasConcept C112705442 @default.
• W2000632124 hasConcept C126322002 @default.
• W2000632124 hasConcept C139254425 @default.
• W2000632124 hasConcept C159641895 @default.
• W2000632124 hasConcept C16005928 @default.
• W2000632124 hasConcept C185592680 @default.
• W2000632124 hasConcept C2779548794 @default.
• W2000632124 hasConcept C2780026642 @default.
• W2000632124 hasConcept C2780651595 @default.
• W2000632124 hasConcept C43376680 @default.
• W2000632124 hasConcept C71924100 @default.
• W2000632124 hasConcept C98274493 @default.
• W2000632124 hasConceptScore W2000632124C108215921 @default.
• W2000632124 hasConceptScore W2000632124C112705442 @default.
• W2000632124 hasConceptScore W2000632124C126322002 @default.
• W2000632124 hasConceptScore W2000632124C139254425 @default.
• W2000632124 hasConceptScore W2000632124C159641895 @default.
• W2000632124 hasConceptScore W2000632124C16005928 @default.
• W2000632124 hasConceptScore W2000632124C185592680 @default.
• W2000632124 hasConceptScore W2000632124C2779548794 @default.
• W2000632124 hasConceptScore W2000632124C2780026642 @default.
• W2000632124 hasConceptScore W2000632124C2780651595 @default.
• W2000632124 hasConceptScore W2000632124C43376680 @default.
• W2000632124 hasConceptScore W2000632124C71924100 @default.
• W2000632124 hasConceptScore W2000632124C98274493 @default.
• W2000632124 hasLocation W20006321241 @default.
• W2000632124 hasLocation W20006321242 @default.
• W2000632124 hasLocation W20006321243 @default.
• W2000632124 hasLocation W20006321244 @default.
• W2000632124 hasOpenAccess W2000632124 @default.
• W2000632124 hasPrimaryLocation W20006321241 @default.
• W2000632124 hasRelatedWork W2024090145 @default.
• W2000632124 hasRelatedWork W2080398286 @default.

• next