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- W2000632630 abstract "•Distantly related pathogens use similar strategies in host cell subversion. •Viruses extensively mimic host short linear motifs to hijack host cell pathways. •Examples of motif mimicry in prokaryotic and eukaryotic parasites are presented. •Host motif mimicry seems to be a common tactic in pathogens from all taxonomic domains. Molecular mimicry is one of the powerful stratagems that pathogens employ to colonise their hosts and take advantage of host cell functions to guarantee their replication and dissemination. In particular, several viruses have evolved the ability to interact with host cell components through protein short linear motifs (SLiMs) that mimic host SLiMs, thus facilitating their internalisation and the manipulation of a wide range of cellular networks. Here we present convincing evidence from the literature that motif mimicry also represents an effective, widespread hijacking strategy in prokaryotic and eukaryotic parasites. Further insights into host motif mimicry would be of great help in the elucidation of the molecular mechanisms behind host cell invasion and the development of anti-infective therapeutic strategies. Molecular mimicry is one of the powerful stratagems that pathogens employ to colonise their hosts and take advantage of host cell functions to guarantee their replication and dissemination. In particular, several viruses have evolved the ability to interact with host cell components through protein short linear motifs (SLiMs) that mimic host SLiMs, thus facilitating their internalisation and the manipulation of a wide range of cellular networks. Here we present convincing evidence from the literature that motif mimicry also represents an effective, widespread hijacking strategy in prokaryotic and eukaryotic parasites. Further insights into host motif mimicry would be of great help in the elucidation of the molecular mechanisms behind host cell invasion and the development of anti-infective therapeutic strategies. a family of evolutionarily conserved proteins that play a key role in multiple biological processes by interacting with a plethora of client proteins. They bind to phosphorylated serine or threonine residues. a component of the type IV secretion system (T4SS) of the gastric pathogen Helicobacter pylori. It is a specialised adhesin of the T4SS pilus interacting via an RGD motif with host α5β3 and α5β1 integrins. It is required for pathogen adhesion to gastric epithelial cells. proteins exported via a type III secretion system and delivered to the host cell to promote maximal cell invasion. an integral membrane protein found on the surface of many cell types in vertebrate animals. a gene family comprising numerous genes that contain conserved CLE domains in various plant species and plant-parasitic nematodes. Plant CLE genes encode small proteins with an N-terminal secretion signal peptide and a conserved 14-amino acid domain called the CLE motif at the C terminus. CLE proteins have roles in shoot, floral, and root meristem maintenance, organ size regulation, apical dominance, and vascular development. an enzyme that phosphorylates tyrosine residues located in the C-terminal end of Src family kinases. a family of important adaptor molecules that participate in diverse signalling pathways and localises to EPEC pedestals. a phosphotyrosine-containing protein that is secreted by the H. pylori type IV secretion system. It induces morphological changes in the infected cell by interacting with proteins of the host's signalling pathways, including Grb2, Shp2, and Csk. a dense granule protein that is exported through the Toxoplasma gondii vacuole membrane and reaches the host cell nucleus, where it positively modulates genes involved in cell cycle progression and the p53 tumour-suppressor pathway. a T. gondii protein secreted from the PV to the host cell nucleus, where it activates host kinases using two high-affinity MAPK-docking motifs. a serine/threonine kinase that plays a critical role in the regulation of cell growth and differentiation. EHEC protein injected through a type III secretion system into host cells, where it stimulates actin polymerisation by activating host WASP proteins. a Pseudomonas aeruginosa type III secretion effector targeting multiple substrates in the host. It exerts complex effects on eukaryotic cell function, including inhibition of DNA synthesis, alterations in cell morphology, microvillus effacement, and loss of cellular adherence. a phytotoxic terpenoid secreted by the fungus Phomopsis amygdali. The terpenoid binds and stabilises the host H+-ATPase–14-3-3 complex, thus irreversibly activating plasma membrane H+-ATPase and inducing uncontrolled stomata opening. an adaptor protein involved in signal transduction. It binds several membrane receptors and contains one SH2 domain and two SH3 domains. a type III effector secreted by Pseudomonas syringae effector protein. It enhances bacterial virulence and associates with host 14-3-3 proteins in a phosphorylation-dependent manner. one of the transmembrane proteins of the chlamydial inclusion, a vacuole in which the Chlamydia trachomatis developmental cycle occurs. a family of heterodimeric receptors that link the surface of cells to various extracellular membrane matrix components. They mediate the transduction of cell–extracellular membrane matrix signalling. a family of proteins involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signalling proteins. It contains SH2 and SH3 domains and interacts with the WASP–Arp2/3 complex to coordinate actin cytoskeletal remodelling. type III secretion system effectors that downregulate the host innate immune response. a class of MAPKs that are responsive to various stress stimuli such as cytokines, lipopolysaccharides, UV light, heat, and osmotic shock. They are also involved in cell differentiation and apoptosis. a Plasmodium falciparum sexual stage-specific protein involved in maintaining cell integrity during the uniquely long gametocytogenesis of the parasite. an essential, calcium-dependent regulator of P. aeruginosa twitching/surface motility. a protein encoded by the var genes. It interacts with adhesion molecules such as ICAM-1, CD36, and TSP via various domains. a host-selective toxin that is internalised into wheat mesophyll cells via RGD motif-mediated interaction with host cell integrins. a P. falciparum type 1 membrane protein that possesses multiple adhesive domains in its extracellular region. It is essential for sporozoite motility and for liver cell invasion. a protein tyrosine phosphatase encoded by the gene PTPN11 and involved in several intracellular signalling pathways. It contains two SH2 domains. conserved docking modules recognising and interacting with phosphorylated tyrosine residues. They are found in several intracellular signalling proteins. conserved docking modules recognising and interacting with polyproline motifs. They are found in several intracellular signalling proteins. one of the effectors delivered into host cells by the EPEC type III secretion system. It drives the major pathway responsible for regulating actin polymerisation in the host cell. a type III effector protein found in phytopathogens of the genus Xanthomonas." @default.
- W2000632630 created "2016-06-24" @default.
- W2000632630 creator A5003051613 @default.
- W2000632630 creator A5027368560 @default.
- W2000632630 creator A5060161630 @default.
- W2000632630 creator A5088248109 @default.
- W2000632630 date "2015-01-01" @default.
- W2000632630 modified "2023-10-12" @default.
- W2000632630 title "How pathogens use linear motifs to perturb host cell networks" @default.
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