FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000634566> ?p ?o ?g. }

• W2000634566 endingPage "1556" @default.
• W2000634566 startingPage "1548" @default.
• W2000634566 abstract "Brain mitochondrial ATP-sensitive K+ channel (mitoK(ATP)) opening by diazoxide protects against ischemic damage and excitotoxic cell death. Here we studied the redox properties of brain mitoK(ATP) . MitoK(ATP) activation during excitotoxicity in cultured cerebellar granule neurons prevented the accumulation of reactive oxygen species (ROS) and cell death. Furthermore, mitoK(ATP) activation in isolated brain mitochondria significantly prevented H2O2 release by these organelles but did not change Ca2+ accumulation capacity. Interestingly, the activity of mitoK(ATP) was highly dependent on redox state. The thiol reductant mercaptopropionylglycine prevented mitoK(ATP) activity, whereas exogenous ROS activated the channel. In addition, the use of mitochondrial substrates that led to higher levels of endogenous mitochondrial ROS release closely correlated with enhanced K+ transport activity through mitoK(ATP). Altogether, our results indicate that brain mitoK(ATP) is a redox-sensitive channel that controls mitochondrial ROS release." @default.
• W2000634566 created "2016-06-24" @default.
• W2000634566 creator A5000445410 @default.
• W2000634566 creator A5020771345 @default.
• W2000634566 creator A5049076742 @default.
• W2000634566 creator A5064753559 @default.
• W2000634566 date "2008-01-01" @default.
• W2000634566 modified "2023-10-16" @default.
• W2000634566 title "Redox properties of the adenoside triphosphate-sensitive K+ channel in brain mitochondria" @default.
• W2000634566 cites W1548755019 @default.
• W2000634566 cites W1576143041 @default.
• W2000634566 cites W1597339748 @default.
• W2000634566 cites W1598578622 @default.
• W2000634566 cites W1827049966 @default.
• W2000634566 cites W1876476959 @default.
• W2000634566 cites W1938199221 @default.
• W2000634566 cites W1976603452 @default.
• W2000634566 cites W1985243477 @default.
• W2000634566 cites W1985977889 @default.
• W2000634566 cites W1987385157 @default.
• W2000634566 cites W1992282049 @default.
• W2000634566 cites W2001679980 @default.
• W2000634566 cites W2003408034 @default.
• W2000634566 cites W2003468545 @default.
• W2000634566 cites W2010935932 @default.
• W2000634566 cites W2016293448 @default.
• W2000634566 cites W2017140295 @default.
• W2000634566 cites W2018611729 @default.
• W2000634566 cites W2021725707 @default.
• W2000634566 cites W2025333162 @default.
• W2000634566 cites W2026437921 @default.
• W2000634566 cites W2026859890 @default.
• W2000634566 cites W2034868973 @default.
• W2000634566 cites W2035705887 @default.
• W2000634566 cites W2039868368 @default.
• W2000634566 cites W2044185633 @default.
• W2000634566 cites W2045201746 @default.
• W2000634566 cites W2047918205 @default.
• W2000634566 cites W2048547503 @default.
• W2000634566 cites W2063772445 @default.
• W2000634566 cites W2068976528 @default.
• W2000634566 cites W2082782176 @default.
• W2000634566 cites W2094247127 @default.
• W2000634566 cites W2100405364 @default.
• W2000634566 cites W2133838366 @default.
• W2000634566 cites W2141660740 @default.
• W2000634566 cites W2157659024 @default.
• W2000634566 cites W2166788705 @default.
• W2000634566 cites W2190690918 @default.
• W2000634566 cites W4247088117 @default.
• W2000634566 doi "https://doi.org/10.1002/jnr.21614" @default.
• W2000634566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18189325" @default.
• W2000634566 hasPublicationYear "2008" @default.
• W2000634566 type Work @default.
• W2000634566 sameAs 2000634566 @default.
• W2000634566 citedByCount "48" @default.
• W2000634566 countsByYear W20006345662013 @default.
• W2000634566 countsByYear W20006345662014 @default.
• W2000634566 countsByYear W20006345662015 @default.
• W2000634566 countsByYear W20006345662016 @default.
• W2000634566 countsByYear W20006345662017 @default.
• W2000634566 countsByYear W20006345662018 @default.
• W2000634566 countsByYear W20006345662019 @default.
• W2000634566 countsByYear W20006345662020 @default.
• W2000634566 countsByYear W20006345662021 @default.
• W2000634566 countsByYear W20006345662023 @default.
• W2000634566 crossrefType "journal-article" @default.
• W2000634566 hasAuthorship W2000634566A5000445410 @default.
• W2000634566 hasAuthorship W2000634566A5020771345 @default.
• W2000634566 hasAuthorship W2000634566A5049076742 @default.
• W2000634566 hasAuthorship W2000634566A5064753559 @default.
• W2000634566 hasConcept C12554922 @default.
• W2000634566 hasConcept C134018914 @default.
• W2000634566 hasConcept C185592680 @default.
• W2000634566 hasConcept C190283241 @default.
• W2000634566 hasConcept C2779306644 @default.
• W2000634566 hasConcept C2779564974 @default.
• W2000634566 hasConcept C2779872217 @default.
• W2000634566 hasConcept C2781012912 @default.
• W2000634566 hasConcept C28859421 @default.
• W2000634566 hasConcept C31573885 @default.
• W2000634566 hasConcept C48349386 @default.
• W2000634566 hasConcept C55493867 @default.
• W2000634566 hasConcept C86803240 @default.
• W2000634566 hasConcept C95444343 @default.
• W2000634566 hasConceptScore W2000634566C12554922 @default.
• W2000634566 hasConceptScore W2000634566C134018914 @default.
• W2000634566 hasConceptScore W2000634566C185592680 @default.
• W2000634566 hasConceptScore W2000634566C190283241 @default.
• W2000634566 hasConceptScore W2000634566C2779306644 @default.
• W2000634566 hasConceptScore W2000634566C2779564974 @default.
• W2000634566 hasConceptScore W2000634566C2779872217 @default.
• W2000634566 hasConceptScore W2000634566C2781012912 @default.
• W2000634566 hasConceptScore W2000634566C28859421 @default.
• W2000634566 hasConceptScore W2000634566C31573885 @default.
• W2000634566 hasConceptScore W2000634566C48349386 @default.
• W2000634566 hasConceptScore W2000634566C55493867 @default.
• W2000634566 hasConceptScore W2000634566C86803240 @default.

• next