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- W2000636734 abstract "ABSTRACT T cells play an important role in the clearance of acute infection and control of hepatitis B virus (HBV) infection during the chronic phase. Chronic HBV is characterized by a weak and limited T-cell response. Several hypotheses, such as presence of Tregs or occurrence of T-cell exhaustion have been proposed to explain these observations. The two registered classes of anti-HBV drugs: pegylated-IFN-α (PEG-IFN-α) and nucleos(t)ide analogs (NUCs) have, next to their antiviral effect, also an immunomodulatory effect. Although NUCs have no direct immunomodulatory effects, they may indirectly positively affect the T-cell response through their viral suppressive action. In this review, effects of both PEG-IFN-α and NUC therapy will be discussed with regard to the cellular immune response against HBV." @default.
- W2000636734 created "2016-06-24" @default.
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- W2000636734 date "2014-10-01" @default.
- W2000636734 modified "2023-09-25" @default.
- W2000636734 title "The influences of antiviral therapy on T-cell function in adult patients with chronic hepatitis B" @default.
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- W2000636734 doi "https://doi.org/10.2217/fvl.14.76" @default.
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