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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000637851> ?p ?o ?g. }

• W2000637851 endingPage "2833" @default.
• W2000637851 startingPage "2829" @default.
• W2000637851 abstract "Interleukin 4 (IL-4) induces the expression of IgG1 and IgE in lipopolysaccharide-stimulated B cells. Previous studies have suggested that heavy-chain class switching may be regulated by increasing the accessibility of specific switch regions to switch recombinases. In this study, we have used an RNase protection assay to demonstrate that IL-4 induces expression of germ-line gamma 1 transcripts in B cells within 4 hr of culture; induction is dose-dependent and is inhibited by interferon gamma. IL-4 alone is capable of inducing the expression of germ-line gamma 1 transcripts in small, resting B cells, but lipopolysaccharide enhances expression. The germ-line transcripts are the same size (1.8 and 3.4 kilobases) as the secreted and membrane forms of the functional gamma 1 mRNAs and presumably result from the splicing of an upstream switch-region exon(s) to the gamma 1 constant-region exon(s). These data strongly support the accessibility model for the regulation of isotype switching and suggest that lymphokines such as IL-4 may direct specific switch events by transcriptional activation of the corresponding switch regions." @default.
• W2000637851 created "2016-06-24" @default.
• W2000637851 creator A5036405811 @default.
• W2000637851 creator A5064429049 @default.
• W2000637851 creator A5084475433 @default.
• W2000637851 date "1989-04-01" @default.
• W2000637851 modified "2023-09-27" @default.
• W2000637851 title "Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma." @default.
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• W2000637851 doi "https://doi.org/10.1073/pnas.86.8.2829" @default.
• W2000637851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/287012" @default.
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