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- W2000640689 abstract "The efficacy, safety and tolerability of calcipotriol cream was compared with betamethasone 17‐valerate cream in the treatment of plaque‐type psoriasis in a multicentre double‐blind, parallel group study. Patients with stable mild‐to‐moderate chronic disease were randomized to treatment with either calcipotriol, 50 μg/g, in a cream formulation (210 patients) or betamethasone 17‐valerate cream, 1 mg/g (211 patients). After a wash‐out period of 2 weeks. the treatment was applied twice daily, without occlusion. for 8 weeks or to complete clearing. The severity of psoriasis was assessed using the PASI at baseline and after 4 and 8 weeks treatment. The mean percentage reduction of PASI from baseline to end of treatment was 47.8% in the calcipotriol group and 45.4% in the betamethasone group. The reduction from baseline was highly significant in both groups. but the differecnce between the groups was not significant. There was a difference in the reduction in thickness of the lesions in favour of calcipotriol. The investigator's as well as the patient's overall assessment of treatment response at end of treatment showed no difference between the two treatment groups. Treatment‐related adverse events were more frequent with calcipotriol thanbetamethasone. Lesional/perilesional irritation was reported in 16% and 9% (P=0.03). and facial irritation in 10% and 0.5% (P<0.001), respectively. No change was found in serum levels of calcium. Calcipotriol in a cream formulation was effective, safe well‐tolerated. and equal in effect to betamethasone valerate cream." @default.
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- W2000640689 date "1997-01-01" @default.
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- W2000640689 title "Comparative efficacy of calcipotriol (MC903) cream and betamethasone 17-valerate cream in the treatment of chronic plaque psoriasis. A randomized, double-blind, parallel group multicentre study" @default.
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- W2000640689 doi "https://doi.org/10.1046/j.1365-2133.1997.d01-1148.x" @default.
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