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- W2000643232 abstract "Abstract The effect of 2-mercaptopropionylglycine (tiopronin), which is widely used for the treatment of various hepatic disorders, on the generation of medullary prostaglandins (PG) E2 and F2α has been examined. Tiopronin had a potent inhibitory effect on PG E2 formation. Simultaneously, PG F2α production was increased. In the presence of tiopronin the net increased amount of PG F2α was much smaller than the net decreased amount of PG E2 (6–20%). These results suggest that tiopronin has the potential to modulate PG E2 and F2α synthesis by affecting endoperoxide E2 isomerase or endoperoxide reductase and that this effect may represent some pharmacological action of the drug." @default.
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- W2000643232 date "1988-09-01" @default.
- W2000643232 modified "2023-10-16" @default.
- W2000643232 title "Effect of tiopronin on prostaglandin synthesis in rabbit kidney medulla slices" @default.
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- W2000643232 doi "https://doi.org/10.1111/j.2042-7158.1988.tb05329.x" @default.
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