FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000643610> ?p ?o ?g. }

• W2000643610 endingPage "1465" @default.
• W2000643610 startingPage "1455" @default.
• W2000643610 abstract "Ferritins are biological iron chelators that can sequestrate excess iron to maintain iron homeostasis in the body. Ferritins basically consist of 2 types of subunits, designated as H and L. However, another new subunit, ferritin M which possesses characteristic features of both the H and L subunits, was recently identified in lower vertebrates, mostly in fish. In this study, a ferritin M-like subunit from rock bream (Oplegnathus fasciatus) (RbFerM) was characterized at the molecular level, and its transcriptional profile was analyzed in healthy fish, as well as in pathogen- and mitogen-stimulated fish. Furthermore, its functional properties were evaluated using the recombinant protein. The complete coding sequence of RbFerM was 528 bp in length, encoding a 176-amino acid peptide with a calculated molecular mass of 20 kDa. In silico analysis of RbFerM revealed that it has features similar to both the mammalian ferritin subunits, H and L. Phylogenetic analysis depicted the higher evolutionary proximity of RbFerM with its fish counterparts. Quantitative real time polymerase chain reaction (PCR) analysis detected a ubiquitous transcriptional profile of RbFerM in selected tissues of rock bream, in which more pronounced expression was observed in blood and liver tissues. Significant transcriptional inductions of RbFerM were detected in liver tissues upon lipopolysaccharides (LPS), Edwardsiella tarda, Streptococcus iniae, and rock bream irido virus (RBIV) exposures in time-course immune-challenge experiments. The purified recombinant protein of RbFerM demonstrated detectable iron chelating activity that varied with the temperature. Moreover, the recombinant RbFerM rendered a detectable protection effect against iron (II) and H2O2-mediated DNA damage." @default.
• W2000643610 created "2016-06-24" @default.
• W2000643610 creator A5030480121 @default.
• W2000643610 creator A5031163028 @default.
• W2000643610 creator A5039168336 @default.
• W2000643610 creator A5044058443 @default.
• W2000643610 creator A5058672519 @default.
• W2000643610 creator A5069596946 @default.
• W2000643610 creator A5078515384 @default.
• W2000643610 date "2013-11-01" @default.
• W2000643610 modified "2023-09-27" @default.
• W2000643610 title "A teleostean counterpart of ferritin M subunit from rock bream (Oplegnathus fasciatus): An active constituent in iron chelation and DNA protection against oxidative damage, with a modulated expression upon pathogen stress" @default.
• W2000643610 cites W1530978561 @default.
• W2000643610 cites W1710867374 @default.
• W2000643610 cites W1967285463 @default.
• W2000643610 cites W1969296748 @default.
• W2000643610 cites W1972666164 @default.
• W2000643610 cites W197437642 @default.
• W2000643610 cites W1974801563 @default.
• W2000643610 cites W1975281913 @default.
• W2000643610 cites W1978882591 @default.
• W2000643610 cites W1979334696 @default.
• W2000643610 cites W1987119816 @default.
• W2000643610 cites W1989078299 @default.
• W2000643610 cites W1989860945 @default.
• W2000643610 cites W1991702331 @default.
• W2000643610 cites W1997372388 @default.
• W2000643610 cites W1997977268 @default.
• W2000643610 cites W2007097296 @default.
• W2000643610 cites W2015894758 @default.
• W2000643610 cites W2020030307 @default.
• W2000643610 cites W2039674728 @default.
• W2000643610 cites W2043289078 @default.
• W2000643610 cites W2049856962 @default.
• W2000643610 cites W2051068588 @default.
• W2000643610 cites W2052117680 @default.
• W2000643610 cites W2056836881 @default.
• W2000643610 cites W2057138726 @default.
• W2000643610 cites W2063325494 @default.
• W2000643610 cites W2069280438 @default.
• W2000643610 cites W2069512202 @default.
• W2000643610 cites W2070766674 @default.
• W2000643610 cites W2074685327 @default.
• W2000643610 cites W2080621208 @default.
• W2000643610 cites W2081244740 @default.
• W2000643610 cites W2082509603 @default.
• W2000643610 cites W2085782389 @default.
• W2000643610 cites W2086556027 @default.
• W2000643610 cites W2086567353 @default.
• W2000643610 cites W2090834142 @default.
• W2000643610 cites W2101128002 @default.
• W2000643610 cites W2107277218 @default.
• W2000643610 cites W2108816504 @default.
• W2000643610 cites W2118745767 @default.
• W2000643610 cites W2119605126 @default.
• W2000643610 cites W2123200029 @default.
• W2000643610 cites W2125121305 @default.
• W2000643610 cites W2142964320 @default.
• W2000643610 cites W2153839710 @default.
• W2000643610 cites W2157296374 @default.
• W2000643610 cites W2164631866 @default.
• W2000643610 cites W2164805147 @default.
• W2000643610 cites W4245411846 @default.
• W2000643610 cites W4293247451 @default.
• W2000643610 doi "https://doi.org/10.1016/j.fsi.2013.08.012" @default.
• W2000643610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23978565" @default.
• W2000643610 hasPublicationYear "2013" @default.
• W2000643610 type Work @default.
• W2000643610 sameAs 2000643610 @default.
• W2000643610 citedByCount "20" @default.
• W2000643610 countsByYear W20006436102014 @default.
• W2000643610 countsByYear W20006436102015 @default.
• W2000643610 countsByYear W20006436102016 @default.
• W2000643610 countsByYear W20006436102017 @default.
• W2000643610 countsByYear W20006436102018 @default.
• W2000643610 countsByYear W20006436102019 @default.
• W2000643610 countsByYear W20006436102020 @default.
• W2000643610 countsByYear W20006436102021 @default.
• W2000643610 countsByYear W20006436102022 @default.
• W2000643610 countsByYear W20006436102023 @default.
• W2000643610 crossrefType "journal-article" @default.
• W2000643610 hasAuthorship W2000643610A5030480121 @default.
• W2000643610 hasAuthorship W2000643610A5031163028 @default.
• W2000643610 hasAuthorship W2000643610A5039168336 @default.
• W2000643610 hasAuthorship W2000643610A5044058443 @default.
• W2000643610 hasAuthorship W2000643610A5058672519 @default.
• W2000643610 hasAuthorship W2000643610A5069596946 @default.
• W2000643610 hasAuthorship W2000643610A5078515384 @default.
• W2000643610 hasConcept C104292427 @default.
• W2000643610 hasConcept C104317684 @default.
• W2000643610 hasConcept C153911025 @default.
• W2000643610 hasConcept C2775905019 @default.
• W2000643610 hasConcept C2776151105 @default.
• W2000643610 hasConcept C2776832872 @default.
• W2000643610 hasConcept C2778319317 @default.
• W2000643610 hasConcept C2778815482 @default.
• W2000643610 hasConcept C40767141 @default.
• W2000643610 hasConcept C55493867 @default.

• next