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• W2000644342 abstract "A series of [Pt(ii)Cl2(4,4′-dialkoxy-2,2′-bipyridine)] complexes of the general formula of [Pt(ii)Cl2(4,4′-bis(RO)-2,2′-bipyridine)] (where R = –(CH2)n−1CH3, n = 2–6, 8) were synthesized and characterized using 1H NMR, 13C NMR spectroscopy, elemental analysis, mass spectroscopy, and differential scanning calorimetry measurements. The in vitro anti-proliferative activities of these compounds were evaluated against human cancer cell lines A549 (lung adenocarcinoma), DU145 (prostate carcinoma), MCF-7 (breast adenocarcinoma), and MDA-MB-435 (melanoma) using the MTS cell proliferation assay. Several Pt(ii) coordination compounds were found to have greatly enhanced activity compared to cisplatin after a one hour treatment in all cell lines tested. A structure–activity relationship was observed, that is, the activity increases as the carbon chain length of the alkyl group increases. The activity was maximum when the carbon chain length reached four or five carbons and decreased with the longer carbon chain length. Fluorescence microscopy and flow cytometry data indicate that the main mode of cell death is through apoptosis with some necrotic responses. Described herein is the synthesis of a series of [PtCl2(4,4′-dialkoxy-2,2′-bipyridine)] complexes and their in vitro anticancer activities. They were found to be more potent than cisplatin in inhibiting cell proliferation." @default.
• W2000644342 created "2016-06-24" @default.
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• W2000644342 date "2013-01-01" @default.
• W2000644342 modified "2023-09-25" @default.
• W2000644342 title "Synthesis of [PtCl2(4,4′-dialkoxy-2,2′-bipyridine)] complexes and their in vitro anticancer properties" @default.
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• W2000644342 doi "https://doi.org/10.1039/c3mt00128h" @default.
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