FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000644554> ?p ?o ?g. }

• W2000644554 endingPage "282" @default.
• W2000644554 startingPage "273" @default.
• W2000644554 abstract "Intravesical bacillus Calmette-Guerin (BCG) is currently the therapy of choice for superficial bladder cancer with a 60-70% response rate. Induction of cytokine production (e.g. IL-6, etc.) by BCG has been found in patient's urine in vivo as well as bladder cancer cell lines. However, the signalling mechanisms are still unclear. In this study, we investigated the effect of BCG on cAMP production and its role in regulating interleukin-6 expression in the human bladder cancer cell line, MGH. After 1 hr exposure to BCG, IL-6 gene expression in MGH cells increased by 2.5-3-fold and cAMP production increased by 8-10-fold in a time- and dose-dependent manner. BCG-induced cAMP production was inhibited by both antifibronectin antibody and an adenylate cyclase inhibitor, SQ22536 in a dose-dependent way. In the presence of SQ22536, IL-6 expression in MGH cells was also greatly reduced. Furthermore, cAMP-dependent kinase inhibitors H7 and HA1004 also inhibited BCG-induced IL-6 expression in MGH, with HA1004 being much less effective than H7. Thus, BCG induces cAMP production and may regulate interleukin-6 expression partially via a cAMP-dependent pathway in human bladder cancer cells." @default.
• W2000644554 created "2016-06-24" @default.
• W2000644554 creator A5000431183 @default.
• W2000644554 creator A5025077654 @default.
• W2000644554 creator A5044177167 @default.
• W2000644554 creator A5082117229 @default.
• W2000644554 creator A5084975407 @default.
• W2000644554 date "2002-01-01" @default.
• W2000644554 modified "2023-10-18" @default.
• W2000644554 title "The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells" @default.
• W2000644554 cites W176965263 @default.
• W2000644554 cites W1984794796 @default.
• W2000644554 cites W1984839677 @default.
• W2000644554 cites W2001668668 @default.
• W2000644554 cites W2012551910 @default.
• W2000644554 cites W2016641823 @default.
• W2000644554 cites W2057704084 @default.
• W2000644554 cites W2076733228 @default.
• W2000644554 cites W2092165857 @default.
• W2000644554 cites W2093207937 @default.
• W2000644554 cites W2400642983 @default.
• W2000644554 cites W2403922269 @default.
• W2000644554 cites W2408734958 @default.
• W2000644554 cites W2412492782 @default.
• W2000644554 cites W2419632979 @default.
• W2000644554 cites W2460892140 @default.
• W2000644554 cites W4243650202 @default.
• W2000644554 cites W4301727782 @default.
• W2000644554 doi "https://doi.org/10.1016/s0006-2952(01)00831-0" @default.
• W2000644554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11841803" @default.
• W2000644554 hasPublicationYear "2002" @default.
• W2000644554 type Work @default.
• W2000644554 sameAs 2000644554 @default.
• W2000644554 citedByCount "14" @default.
• W2000644554 countsByYear W20006445542012 @default.
• W2000644554 countsByYear W20006445542013 @default.
• W2000644554 countsByYear W20006445542014 @default.
• W2000644554 countsByYear W20006445542018 @default.
• W2000644554 countsByYear W20006445542021 @default.
• W2000644554 countsByYear W20006445542022 @default.
• W2000644554 crossrefType "journal-article" @default.
• W2000644554 hasAuthorship W2000644554A5000431183 @default.
• W2000644554 hasAuthorship W2000644554A5025077654 @default.
• W2000644554 hasAuthorship W2000644554A5044177167 @default.
• W2000644554 hasAuthorship W2000644554A5082117229 @default.
• W2000644554 hasAuthorship W2000644554A5084975407 @default.
• W2000644554 hasConcept C121608353 @default.
• W2000644554 hasConcept C126322002 @default.
• W2000644554 hasConcept C150903083 @default.
• W2000644554 hasConcept C170493617 @default.
• W2000644554 hasConcept C180526460 @default.
• W2000644554 hasConcept C203014093 @default.
• W2000644554 hasConcept C207001950 @default.
• W2000644554 hasConcept C2778690821 @default.
• W2000644554 hasConcept C2780352672 @default.
• W2000644554 hasConcept C2992454250 @default.
• W2000644554 hasConcept C502942594 @default.
• W2000644554 hasConcept C54355233 @default.
• W2000644554 hasConcept C71924100 @default.
• W2000644554 hasConcept C81885089 @default.
• W2000644554 hasConcept C86803240 @default.
• W2000644554 hasConcept C8891405 @default.
• W2000644554 hasConcept C98274493 @default.
• W2000644554 hasConceptScore W2000644554C121608353 @default.
• W2000644554 hasConceptScore W2000644554C126322002 @default.
• W2000644554 hasConceptScore W2000644554C150903083 @default.
• W2000644554 hasConceptScore W2000644554C170493617 @default.
• W2000644554 hasConceptScore W2000644554C180526460 @default.
• W2000644554 hasConceptScore W2000644554C203014093 @default.
• W2000644554 hasConceptScore W2000644554C207001950 @default.
• W2000644554 hasConceptScore W2000644554C2778690821 @default.
• W2000644554 hasConceptScore W2000644554C2780352672 @default.
• W2000644554 hasConceptScore W2000644554C2992454250 @default.
• W2000644554 hasConceptScore W2000644554C502942594 @default.
• W2000644554 hasConceptScore W2000644554C54355233 @default.
• W2000644554 hasConceptScore W2000644554C71924100 @default.
• W2000644554 hasConceptScore W2000644554C81885089 @default.
• W2000644554 hasConceptScore W2000644554C86803240 @default.
• W2000644554 hasConceptScore W2000644554C8891405 @default.
• W2000644554 hasConceptScore W2000644554C98274493 @default.
• W2000644554 hasIssue "2" @default.
• W2000644554 hasLocation W20006445541 @default.
• W2000644554 hasLocation W20006445542 @default.
• W2000644554 hasOpenAccess W2000644554 @default.
• W2000644554 hasPrimaryLocation W20006445541 @default.
• W2000644554 hasRelatedWork W181678093 @default.
• W2000644554 hasRelatedWork W1993985418 @default.
• W2000644554 hasRelatedWork W2005666125 @default.
• W2000644554 hasRelatedWork W2047209980 @default.
• W2000644554 hasRelatedWork W2052769723 @default.
• W2000644554 hasRelatedWork W2095433947 @default.
• W2000644554 hasRelatedWork W3017248443 @default.
• W2000644554 hasRelatedWork W3138050922 @default.
• W2000644554 hasRelatedWork W2185732136 @default.
• W2000644554 hasRelatedWork W2396811992 @default.
• W2000644554 hasVolume "63" @default.
• W2000644554 isParatext "false" @default.
• W2000644554 isRetracted "false" @default.

• next