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- W2000647744 abstract "A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation. These same effects are observed upon administration of recombinant OPG into normal mice. In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG. Furthermore, OPG blocks ovariectomy-associated bone loss in rats. These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity." @default.
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- W2000647744 date "1997-04-01" @default.
- W2000647744 modified "2023-10-09" @default.
- W2000647744 title "Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density" @default.
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- W2000647744 doi "https://doi.org/10.1016/s0092-8674(00)80209-3" @default.
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