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- W2000648047 abstract "A new class of alkylated chalcones and flavanones was synthesised and screened for antituberculosis, antixoidant, and cytotoxic activities. The desired compounds were synthesised using methyl substituted 2-hydroxyacetophenone as a key intermediate. The acetophenone derivative having methyl substitution was prepared in turn from methtylated phloroglucinol by formylation (by Vilsmeier-Haack reaction), followed by reduction with Wolf-Kishnner approach, and finally acetylation was involved. Among 17 compounds, compound 5 and compound 4a inhibited M. tuberculosis at minimum inhibitory concentration (MIC) in the range between 25 μ g/mL and 50 μ g/mL. The remaining other 15 compounds also potently inhibited M. tuberculosis at MIC in range between 50 μ g/mL and 100 μ g/mL. Some of these compounds also showed moderate antioxidant and cytotoxic activities." @default.
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- W2000648047 date "2013-01-01" @default.
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- W2000648047 title "Synthesis of (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mo mathvariant=bold>±</mml:mo></mml:mrow></mml:math>)-Pisonivanone and Other Analogs as Potent Antituberculosis Agents" @default.
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- W2000648047 doi "https://doi.org/10.1155/2013/961201" @default.
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