Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000648375> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2000648375 endingPage "701" @default.
- W2000648375 startingPage "699" @default.
- W2000648375 abstract "NADPH oxidase is a cellular enzyme devoted to the production of reactive oxygen species (ROS). NOX4 and NOX2 are the main isoforms of NADPH oxidase in the cardiovascular system. In our recent study, we demonstrated that NOX4, but not NOX2, is a critical mediator of the cardiomyocyte adaptive response to energy stress. NOX4 activity and protein levels are increased in the endoplasmic reticulum (ER) but not in mitochondria of cardiomyocytes during the early phase of energy deprivation. NOX4-derived production of ROS in the ER is a critical event that activates autophagy through stimulation of the EIF2AK3/PERK-EIF2S1/eIF-2α-ATF4 pathway. NOX4-dependent autophagy is an important mechanism to preserve cellular energy and limit cell death in energy-deprived cardiomyocytes. Aside from elucidating a crucial physiological function of NOX4 during cellular energy stress, our study dissects a novel signaling mechanism that regulates autophagy under this condition." @default.
- W2000648375 created "2016-06-24" @default.
- W2000648375 creator A5031467506 @default.
- W2000648375 creator A5054282642 @default.
- W2000648375 creator A5091471046 @default.
- W2000648375 date "2014-01-31" @default.
- W2000648375 modified "2023-09-26" @default.
- W2000648375 title "NOX4 regulates autophagy during energy deprivation" @default.
- W2000648375 doi "https://doi.org/10.4161/auto.27955" @default.
- W2000648375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4091158" @default.
- W2000648375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24492492" @default.
- W2000648375 hasPublicationYear "2014" @default.
- W2000648375 type Work @default.
- W2000648375 sameAs 2000648375 @default.
- W2000648375 citedByCount "46" @default.
- W2000648375 countsByYear W20006483752014 @default.
- W2000648375 countsByYear W20006483752015 @default.
- W2000648375 countsByYear W20006483752016 @default.
- W2000648375 countsByYear W20006483752017 @default.
- W2000648375 countsByYear W20006483752018 @default.
- W2000648375 countsByYear W20006483752019 @default.
- W2000648375 countsByYear W20006483752020 @default.
- W2000648375 countsByYear W20006483752021 @default.
- W2000648375 countsByYear W20006483752022 @default.
- W2000648375 countsByYear W20006483752023 @default.
- W2000648375 crossrefType "journal-article" @default.
- W2000648375 hasAuthorship W2000648375A5031467506 @default.
- W2000648375 hasAuthorship W2000648375A5054282642 @default.
- W2000648375 hasAuthorship W2000648375A5091471046 @default.
- W2000648375 hasBestOaLocation W20006483751 @default.
- W2000648375 hasConcept C104317684 @default.
- W2000648375 hasConcept C139447449 @default.
- W2000648375 hasConcept C158617107 @default.
- W2000648375 hasConcept C190283241 @default.
- W2000648375 hasConcept C203522944 @default.
- W2000648375 hasConcept C2107291 @default.
- W2000648375 hasConcept C2776151105 @default.
- W2000648375 hasConcept C2779719074 @default.
- W2000648375 hasConcept C2779765511 @default.
- W2000648375 hasConcept C2781331208 @default.
- W2000648375 hasConcept C28859421 @default.
- W2000648375 hasConcept C48349386 @default.
- W2000648375 hasConcept C54458228 @default.
- W2000648375 hasConcept C55493867 @default.
- W2000648375 hasConcept C67705224 @default.
- W2000648375 hasConcept C86803240 @default.
- W2000648375 hasConcept C95444343 @default.
- W2000648375 hasConceptScore W2000648375C104317684 @default.
- W2000648375 hasConceptScore W2000648375C139447449 @default.
- W2000648375 hasConceptScore W2000648375C158617107 @default.
- W2000648375 hasConceptScore W2000648375C190283241 @default.
- W2000648375 hasConceptScore W2000648375C203522944 @default.
- W2000648375 hasConceptScore W2000648375C2107291 @default.
- W2000648375 hasConceptScore W2000648375C2776151105 @default.
- W2000648375 hasConceptScore W2000648375C2779719074 @default.
- W2000648375 hasConceptScore W2000648375C2779765511 @default.
- W2000648375 hasConceptScore W2000648375C2781331208 @default.
- W2000648375 hasConceptScore W2000648375C28859421 @default.
- W2000648375 hasConceptScore W2000648375C48349386 @default.
- W2000648375 hasConceptScore W2000648375C54458228 @default.
- W2000648375 hasConceptScore W2000648375C55493867 @default.
- W2000648375 hasConceptScore W2000648375C67705224 @default.
- W2000648375 hasConceptScore W2000648375C86803240 @default.
- W2000648375 hasConceptScore W2000648375C95444343 @default.
- W2000648375 hasIssue "4" @default.
- W2000648375 hasLocation W20006483751 @default.
- W2000648375 hasLocation W20006483752 @default.
- W2000648375 hasLocation W20006483753 @default.
- W2000648375 hasLocation W20006483754 @default.
- W2000648375 hasOpenAccess W2000648375 @default.
- W2000648375 hasPrimaryLocation W20006483751 @default.
- W2000648375 hasRelatedWork W1496672822 @default.
- W2000648375 hasRelatedWork W1998895168 @default.
- W2000648375 hasRelatedWork W2000648375 @default.
- W2000648375 hasRelatedWork W2005559461 @default.
- W2000648375 hasRelatedWork W2009062388 @default.
- W2000648375 hasRelatedWork W2072667779 @default.
- W2000648375 hasRelatedWork W2186141424 @default.
- W2000648375 hasRelatedWork W2339673893 @default.
- W2000648375 hasRelatedWork W3120897771 @default.
- W2000648375 hasRelatedWork W3142122528 @default.
- W2000648375 hasVolume "10" @default.
- W2000648375 isParatext "false" @default.
- W2000648375 isRetracted "false" @default.
- W2000648375 magId "2000648375" @default.
- W2000648375 workType "article" @default.