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• W2000648519 endingPage "150" @default.
• W2000648519 startingPage "133" @default.
• W2000648519 abstract "For more than 30 yrs allogeneic hematopoietic stem cell transplantations have been successfully performed in patients with hematologic malignancies and bone marrow aplasia. Over the years the field of transplantation has changed dramatically. More and more unrelated donors became available, regimens for haploidentical transplantations were introduced and G-CSF mobilized peripheral blood stem cells and fetal cells from umbilical cord became available as alternate sources of hematopoietic stem cells. However, especially the introduction of donor lymphocyte infusions (DLI) for the successful treatment of leukemic relapses after allogeneic stem cell transplantations improved our understanding of transplantation immunology and opened amazing perspectives in allogeneic transplantation. It was long believed, that myeloablative therapy with high-dose chemotherapy and total body irradiation (TBI) are the sole antileukemic principles in allogeneic transplantations. But by now it became clear, that donor lymphocytes exert a very potent antileukemic effect, now referred as the graft-versus-leukemia (GVL) or graft-versus-malignancy (GVM) reaction. The efficacy of DLI in controlling leukemic relapses suggests that myeloablative therapy is not essential for long-term disease control. By exploiting the GVL or GVM reaction more intensively the role of chemotherapy and TBI is changing to immunosuppression. Sufficient immunosuppression to allow grafting, however, can be achieved with much lower doses as those which have been used in conventional transplants. Therefore allogeneic transplants have become also available for the elderly or for patients with concurrent medical conditions, which would have excluded them from conventional transplants. Moreover, this allogeneic transplantation strategy with reduced intensity conditioning is now also under investigation in patients with susceptible solid tumors and autoimmune diseases. However, one major obstacle in allogeneic transplantations, namely the graft-versus-host disease (GVHD), remains to be solved." @default.
• W2000648519 created "2016-06-24" @default.
• W2000648519 creator A5014507337 @default.
• W2000648519 date "2000-10-01" @default.
• W2000648519 modified "2023-10-14" @default.
• W2000648519 title "Adoptive allogeneic immunotherapy – history and future perspectives" @default.
• W2000648519 cites W106695551 @default.
• W2000648519 cites W121638319 @default.
• W2000648519 cites W125081235 @default.
• W2000648519 cites W1274344746 @default.
• W2000648519 cites W1479909146 @default.
• W2000648519 cites W1490838907 @default.
• W2000648519 cites W1508187469 @default.
• W2000648519 cites W1510992271 @default.
• W2000648519 cites W1511009642 @default.
• W2000648519 cites W151799953 @default.
• W2000648519 cites W1520101281 @default.
• W2000648519 cites W1545991364 @default.
• W2000648519 cites W15483175 @default.
• W2000648519 cites W156080801 @default.
• W2000648519 cites W1582339002 @default.
• W2000648519 cites W1589162162 @default.
• W2000648519 cites W1707184873 @default.
• W2000648519 cites W175951554 @default.
• W2000648519 cites W185283559 @default.
• W2000648519 cites W1873141201 @default.
• W2000648519 cites W1883328448 @default.
• W2000648519 cites W1894913781 @default.
• W2000648519 cites W1912762949 @default.
• W2000648519 cites W1965119257 @default.
• W2000648519 cites W1968113004 @default.
• W2000648519 cites W1971573605 @default.
• W2000648519 cites W1973378675 @default.
• W2000648519 cites W1973712147 @default.
• W2000648519 cites W1976183578 @default.
• W2000648519 cites W1978657243 @default.
• W2000648519 cites W1991026262 @default.
• W2000648519 cites W19910863 @default.
• W2000648519 cites W1995133626 @default.
• W2000648519 cites W1998811121 @default.
• W2000648519 cites W2000676524 @default.
• W2000648519 cites W2002397046 @default.
• W2000648519 cites W2003033387 @default.
• W2000648519 cites W2005037046 @default.
• W2000648519 cites W2007342600 @default.
• W2000648519 cites W2009169660 @default.
• W2000648519 cites W2017902684 @default.
• W2000648519 cites W2020661968 @default.
• W2000648519 cites W2021522146 @default.
• W2000648519 cites W2024639475 @default.
• W2000648519 cites W2028207500 @default.
• W2000648519 cites W2028475115 @default.
• W2000648519 cites W2036334656 @default.
• W2000648519 cites W2037526747 @default.
• W2000648519 cites W2042775079 @default.
• W2000648519 cites W2062045424 @default.
• W2000648519 cites W2066731992 @default.
• W2000648519 cites W2071989019 @default.
• W2000648519 cites W2073798411 @default.
• W2000648519 cites W2081076752 @default.
• W2000648519 cites W2084472791 @default.
• W2000648519 cites W2087653021 @default.
• W2000648519 cites W2087817425 @default.
• W2000648519 cites W2090263060 @default.
• W2000648519 cites W2093452703 @default.
• W2000648519 cites W2112041130 @default.
• W2000648519 cites W2126484153 @default.
• W2000648519 cites W2154101238 @default.
• W2000648519 cites W2167541030 @default.
• W2000648519 cites W2196875085 @default.
• W2000648519 cites W2204379292 @default.
• W2000648519 cites W2215755623 @default.
• W2000648519 cites W2226146977 @default.
• W2000648519 cites W2246362970 @default.
• W2000648519 cites W2255034921 @default.
• W2000648519 cites W2257559310 @default.
• W2000648519 cites W2297816245 @default.
• W2000648519 cites W2315152253 @default.
• W2000648519 cites W2318099690 @default.
• W2000648519 cites W2321645223 @default.
• W2000648519 cites W2327705273 @default.
• W2000648519 cites W2335166576 @default.
• W2000648519 cites W2340547456 @default.
• W2000648519 cites W2400663726 @default.
• W2000648519 cites W2401486119 @default.
• W2000648519 cites W2416148102 @default.
• W2000648519 cites W2416716216 @default.
• W2000648519 cites W2429410018 @default.
• W2000648519 cites W296347676 @default.
• W2000648519 cites W2994278325 @default.
• W2000648519 cites W3112353337 @default.
• W2000648519 cites W339877517 @default.
• W2000648519 cites W34177217 @default.
• W2000648519 cites W4237002847 @default.
• W2000648519 cites W4243138485 @default.
• W2000648519 cites W4244166141 @default.
• W2000648519 cites W4244712895 @default.
• W2000648519 cites W4245517837 @default.

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