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• W2000650296 abstract "A bstract : Skeletal muscle is the largest single organ of the body. Skeletal muscle damage may lead to loss of muscle function, and widespread muscle damage may have serious systemic implications due to leakage of intracellular constituents to the circulation. Ca 2+ acts as a second messenger in all muscle and may activate a whole range of processes ranging from activation of contraction to degradation of the muscle cell. It is therefore of vital importance for the muscle cell to control [Ca 2+ ] in the cytoplasm ([Ca 2+ ] c ). If the permeability of the sarcolemma for Ca 2+ is increased, the muscle cell may suffer Ca 2+ overload, defined as an inability to control [Ca 2+ ] c . This could lead to the activation of calpains, resulting in proteolysis of cellular constituents, activation of phospholipase A 2 (PLA 2 ), affecting membrane integrity, an increased production of reactive oxygen species (ROS), causing lipid peroxidation, and possibly mitochondrial Ca 2+ overload, all of which may further worsen the damage in a self‐reinforcing process. An increased influx of Ca 2+ leading to Ca 2+ overload in muscle may occur in a range of situations such as exercise, mechanical and electrical trauma, prolonged ischemia, Duchenne muscular dystrophy, and cachexia. Counteractions include membrane stabilizing agents, Ca 2+ channel blockers, calpain inhibitors, PLA 2 inhibitors, and ROS scavengers." @default.
• W2000650296 created "2016-06-24" @default.
• W2000650296 creator A5090706915 @default.
• W2000650296 date "2006-03-01" @default.
• W2000650296 modified "2023-10-10" @default.
• W2000650296 title "The Role of Ca²⁺ in Muscle Cell Damage" @default.
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• W2000650296 doi "https://doi.org/10.1196/annals.1363.013" @default.
• W2000650296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16533926" @default.
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