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- W2000650574 abstract "The synthesis of milrinone analogues where the 4-pyridyl moiety was replaced by an ester or amide group is reported. Only amide derivatives are able to support intracellular calcium influx following chemical depolarization with 60 mM KCl in a percentage varying from 20 to 45% of differentiated H9C2 cardiomyocytes. Those cells were differentiated after chronic exposure to 10 nM retinoic acid which induces the expression of voltage-gated calcium channels. Analogues of milrinone containing an ester function did not show significant activity." @default.
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- W2000650574 date "2010-11-01" @default.
- W2000650574 modified "2023-09-25" @default.
- W2000650574 title "Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells" @default.
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- W2000650574 doi "https://doi.org/10.1016/j.ejmech.2010.08.001" @default.
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