Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000651006> ?p ?o ?g. }
- W2000651006 endingPage "1696" @default.
- W2000651006 startingPage "1686" @default.
- W2000651006 abstract "The Wnt/β-catenin pathway and Nanog are key regulators of embryonic stem cell (ESC) pluripotency and the reprogramming of somatic cells. Here, we demonstrate that the repression of Dkk1 by Nanog, which leads indirectly to β-catenin activation, is essential for reprogramming after fusion of ESCs overexpressing Nanog. In addition, β-catenin is necessary in Nanog-dependent conversion of preinduced pluripotent stem cells (pre-iPSCs) into iPSCs. The activation of β-catenin by Nanog causes fluctuations of β-catenin in ESCs cultured in serum plus leukemia inhibitory factor (serum+LIF) medium, in which protein levels of key pluripotency factors are heterogeneous. In 2i+LIF medium, which favors propagation of ESCs in a ground state of pluripotency with many pluripotency genes losing mosaic expression, we show Nanog-independent β-catenin fluctuations. Overall, we demonstrate Nanog and β-catenin cooperation in establishing naive pluripotency during the reprogramming process and their correlated heterogeneity in ESCs primed toward differentiation." @default.
- W2000651006 created "2016-06-24" @default.
- W2000651006 creator A5013604041 @default.
- W2000651006 creator A5033615034 @default.
- W2000651006 creator A5047211034 @default.
- W2000651006 creator A5049232172 @default.
- W2000651006 creator A5060401447 @default.
- W2000651006 creator A5091430819 @default.
- W2000651006 date "2014-09-01" @default.
- W2000651006 modified "2023-10-09" @default.
- W2000651006 title "β-Catenin Fluctuates in Mouse ESCs and Is Essential for Nanog-Mediated Reprogramming of Somatic Cells to Pluripotency" @default.
- W2000651006 cites W1536396898 @default.
- W2000651006 cites W1966758700 @default.
- W2000651006 cites W1967073403 @default.
- W2000651006 cites W1970473429 @default.
- W2000651006 cites W1978842800 @default.
- W2000651006 cites W1987983547 @default.
- W2000651006 cites W1996984755 @default.
- W2000651006 cites W1999541949 @default.
- W2000651006 cites W2002511118 @default.
- W2000651006 cites W2010608530 @default.
- W2000651006 cites W2018965952 @default.
- W2000651006 cites W2029145857 @default.
- W2000651006 cites W2035047647 @default.
- W2000651006 cites W2039912699 @default.
- W2000651006 cites W2041472984 @default.
- W2000651006 cites W2048786084 @default.
- W2000651006 cites W2058521801 @default.
- W2000651006 cites W2067056027 @default.
- W2000651006 cites W2070343627 @default.
- W2000651006 cites W2072806829 @default.
- W2000651006 cites W2076612253 @default.
- W2000651006 cites W2077431122 @default.
- W2000651006 cites W2077827592 @default.
- W2000651006 cites W2079244861 @default.
- W2000651006 cites W2079819294 @default.
- W2000651006 cites W2082822758 @default.
- W2000651006 cites W2084760868 @default.
- W2000651006 cites W2087004817 @default.
- W2000651006 cites W2089426706 @default.
- W2000651006 cites W2096171021 @default.
- W2000651006 cites W2110015307 @default.
- W2000651006 cites W2125916283 @default.
- W2000651006 cites W2126409708 @default.
- W2000651006 cites W2126851387 @default.
- W2000651006 cites W2139965198 @default.
- W2000651006 cites W2142193284 @default.
- W2000651006 cites W2142806844 @default.
- W2000651006 cites W2146098773 @default.
- W2000651006 cites W2146606376 @default.
- W2000651006 cites W2148236785 @default.
- W2000651006 cites W2148272837 @default.
- W2000651006 cites W2150163104 @default.
- W2000651006 cites W2151870437 @default.
- W2000651006 cites W2153004457 @default.
- W2000651006 cites W2155018872 @default.
- W2000651006 cites W2163092257 @default.
- W2000651006 cites W2163679188 @default.
- W2000651006 cites W2319598422 @default.
- W2000651006 doi "https://doi.org/10.1016/j.celrep.2014.08.011" @default.
- W2000651006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25199832" @default.
- W2000651006 hasPublicationYear "2014" @default.
- W2000651006 type Work @default.
- W2000651006 sameAs 2000651006 @default.
- W2000651006 citedByCount "50" @default.
- W2000651006 countsByYear W20006510062015 @default.
- W2000651006 countsByYear W20006510062016 @default.
- W2000651006 countsByYear W20006510062017 @default.
- W2000651006 countsByYear W20006510062018 @default.
- W2000651006 countsByYear W20006510062019 @default.
- W2000651006 countsByYear W20006510062020 @default.
- W2000651006 countsByYear W20006510062021 @default.
- W2000651006 countsByYear W20006510062022 @default.
- W2000651006 crossrefType "journal-article" @default.
- W2000651006 hasAuthorship W2000651006A5013604041 @default.
- W2000651006 hasAuthorship W2000651006A5033615034 @default.
- W2000651006 hasAuthorship W2000651006A5047211034 @default.
- W2000651006 hasAuthorship W2000651006A5049232172 @default.
- W2000651006 hasAuthorship W2000651006A5060401447 @default.
- W2000651006 hasAuthorship W2000651006A5091430819 @default.
- W2000651006 hasBestOaLocation W20006510061 @default.
- W2000651006 hasConcept C104317684 @default.
- W2000651006 hasConcept C107459253 @default.
- W2000651006 hasConcept C134305767 @default.
- W2000651006 hasConcept C145103041 @default.
- W2000651006 hasConcept C1491633281 @default.
- W2000651006 hasConcept C207168726 @default.
- W2000651006 hasConcept C207701140 @default.
- W2000651006 hasConcept C27284151 @default.
- W2000651006 hasConcept C28328180 @default.
- W2000651006 hasConcept C2908926650 @default.
- W2000651006 hasConcept C54355233 @default.
- W2000651006 hasConcept C77255625 @default.
- W2000651006 hasConcept C86803240 @default.
- W2000651006 hasConcept C95444343 @default.
- W2000651006 hasConceptScore W2000651006C104317684 @default.
- W2000651006 hasConceptScore W2000651006C107459253 @default.
- W2000651006 hasConceptScore W2000651006C134305767 @default.