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- W2000651214 abstract "<h3>To the Editor:</h3> With the recent release of sodium adsorbent resins by the Food and Drug Administration, I anticipated that serious difficulties would arise, since the dangers associated with resin administration are not generally known. During the past two years, I have investigated the use of these resins in patients with kidney disease. Most emphasis in the literature, and in the information supplied by the pharmaceutical manufacturers, is placed on the danger of potassium depletion. Equally dangerous is the rapid development of acidosis in the patient whose renal function and base conservation are insufficient to compensate for the release of acid ions. The latter danger is especially pronounced in patients with diabetes mellitus and renal insufficiency. A few days of resin administration, in such patients, may produce profound hypokalemia and acidosis, which may prove fatal. This disaster may occur even with the resins that are partially in the potassium cycle. Since" @default.
- W2000651214 created "2016-06-24" @default.
- W2000651214 creator A5056253861 @default.
- W2000651214 date "1951-05-26" @default.
- W2000651214 modified "2023-10-14" @default.
- W2000651214 title "SODIUM ADSORBENT RESINS—WARNING" @default.
- W2000651214 doi "https://doi.org/10.1001/jama.1951.03670040095027" @default.
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