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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000651798> ?p ?o ?g. }

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• W2000651798 abstract "Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. Inhibitor 10 with a 5-chloropyridinyl ester at position 4 of the indole ring is the most potent inhibitor with a SARS-CoV 3CLpro IC50 value of 30 nM and an antiviral EC50 value of 6.9 μM. Molecular docking studies have provided possible binding modes of these inhibitors." @default.
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• W2000651798 date "2008-10-01" @default.
• W2000651798 modified "2023-10-01" @default.
• W2000651798 title "Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors" @default.
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• W2000651798 doi "https://doi.org/10.1016/j.bmcl.2008.08.082" @default.
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