Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000651976> ?p ?o ?g. }
- W2000651976 endingPage "1773" @default.
- W2000651976 startingPage "1765" @default.
- W2000651976 abstract "The importance of epigenetic aberrations in the pathogenesis of leukemias has been revealed by recurrent gene mutations that highlight epigenetic pathways as well as by the clinical success of therapies like 5-azacytidine and decitabine that work through epigenetic mechanisms. However, precise mechanisms of how gene mutations lead to leukemias and how epigenetic therapies induce clinical remissions are elusive. Current scientific inquiries that take advantage of techniques that can distinguish among the various covalent cytosine modifications at single base resolution are likely to shed light on the ways epigenetic pathways drive leukemogenesis as well as how the hypomethylating drugs induce clinical remissions. The hope is that these studies will also reveal which patients are likely to respond to epigenetic therapies. Thus, the future is likely to bring a new wave of diagnostic and prognostic tools that probe the epigenomics of leukemia to help clinicians in their management of patients." @default.
- W2000651976 created "2016-06-24" @default.
- W2000651976 creator A5013717696 @default.
- W2000651976 creator A5035632991 @default.
- W2000651976 creator A5065240782 @default.
- W2000651976 date "2014-05-20" @default.
- W2000651976 modified "2023-10-17" @default.
- W2000651976 title "The mechanistic role of DNA methylation in myeloid leukemogenesis" @default.
- W2000651976 cites W121905516 @default.
- W2000651976 cites W1865658459 @default.
- W2000651976 cites W1964977164 @default.
- W2000651976 cites W1966010937 @default.
- W2000651976 cites W1967329640 @default.
- W2000651976 cites W1971593803 @default.
- W2000651976 cites W1974747095 @default.
- W2000651976 cites W1976573435 @default.
- W2000651976 cites W1983163251 @default.
- W2000651976 cites W1986654293 @default.
- W2000651976 cites W1989568035 @default.
- W2000651976 cites W1990711772 @default.
- W2000651976 cites W1997998180 @default.
- W2000651976 cites W1998517881 @default.
- W2000651976 cites W2001048063 @default.
- W2000651976 cites W2002625908 @default.
- W2000651976 cites W2002788005 @default.
- W2000651976 cites W2002908974 @default.
- W2000651976 cites W2004291426 @default.
- W2000651976 cites W2006112006 @default.
- W2000651976 cites W2012589963 @default.
- W2000651976 cites W2015493376 @default.
- W2000651976 cites W2015557036 @default.
- W2000651976 cites W2017394727 @default.
- W2000651976 cites W2019203734 @default.
- W2000651976 cites W2019523681 @default.
- W2000651976 cites W2022640617 @default.
- W2000651976 cites W2022733644 @default.
- W2000651976 cites W2025998934 @default.
- W2000651976 cites W2028078153 @default.
- W2000651976 cites W2030808038 @default.
- W2000651976 cites W2034325228 @default.
- W2000651976 cites W2035166160 @default.
- W2000651976 cites W2035409103 @default.
- W2000651976 cites W2038722690 @default.
- W2000651976 cites W2041191257 @default.
- W2000651976 cites W2043472013 @default.
- W2000651976 cites W2057751167 @default.
- W2000651976 cites W2058444707 @default.
- W2000651976 cites W2059099579 @default.
- W2000651976 cites W2066035908 @default.
- W2000651976 cites W2068050716 @default.
- W2000651976 cites W2068590650 @default.
- W2000651976 cites W2071370702 @default.
- W2000651976 cites W2073358648 @default.
- W2000651976 cites W2073587729 @default.
- W2000651976 cites W2078616374 @default.
- W2000651976 cites W2078972833 @default.
- W2000651976 cites W2080486691 @default.
- W2000651976 cites W2081279521 @default.
- W2000651976 cites W2081391009 @default.
- W2000651976 cites W2088621765 @default.
- W2000651976 cites W2092589411 @default.
- W2000651976 cites W2101401770 @default.
- W2000651976 cites W2104076485 @default.
- W2000651976 cites W2106584820 @default.
- W2000651976 cites W2106833395 @default.
- W2000651976 cites W2109150359 @default.
- W2000651976 cites W2113956050 @default.
- W2000651976 cites W2115551519 @default.
- W2000651976 cites W2115707319 @default.
- W2000651976 cites W2116205277 @default.
- W2000651976 cites W2118119661 @default.
- W2000651976 cites W2118771330 @default.
- W2000651976 cites W2121369682 @default.
- W2000651976 cites W2121417064 @default.
- W2000651976 cites W2124729932 @default.
- W2000651976 cites W2125062167 @default.
- W2000651976 cites W2129475502 @default.
- W2000651976 cites W2131072337 @default.
- W2000651976 cites W2133011229 @default.
- W2000651976 cites W2137031237 @default.
- W2000651976 cites W2140929811 @default.
- W2000651976 cites W2142139678 @default.
- W2000651976 cites W2144137532 @default.
- W2000651976 cites W2145750252 @default.
- W2000651976 cites W2148521032 @default.
- W2000651976 cites W2155106329 @default.
- W2000651976 cites W2159249303 @default.
- W2000651976 cites W2168909179 @default.
- W2000651976 cites W2171577249 @default.
- W2000651976 doi "https://doi.org/10.1038/leu.2014.163" @default.
- W2000651976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24913729" @default.
- W2000651976 hasPublicationYear "2014" @default.
- W2000651976 type Work @default.
- W2000651976 sameAs 2000651976 @default.
- W2000651976 citedByCount "31" @default.
- W2000651976 countsByYear W20006519762014 @default.
- W2000651976 countsByYear W20006519762015 @default.
- W2000651976 countsByYear W20006519762016 @default.