Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000653725> ?p ?o ?g. }
- W2000653725 endingPage "335" @default.
- W2000653725 startingPage "327" @default.
- W2000653725 abstract "To study the role of atypical protein kinase C (aPKC) in neurodegenerative disease, we investigated the distribution of PKCι/λ, an aPKC isoform, in a variety of tauopathies and α-synucleinopathies. Immunohistochemical study revealed PKCι/λ within tau-positive neurofibrillary inclusions in Alzheimer disease (AD), progressive supranuclear palsy, corticobasal degeneration (CBD), and Pick disease (PiD), within α-synuclein-positive Lewy bodies in idiopathic Parkinson disease and dementia with Lewy bodies, as well as within glial inclusions in multisystem atrophy. We also observed PKCι/λ label of actin-rich Hirano bodies in AD, PiD, and elderly individuals. Double immunolabeling and fluorescence resonance energy transfer demonstrated close physical association between PKCι/λ and phospho-tau or α-synuclein in some neurofibrillary tangles and Lewy bodies. Furthermore, PKCι/λ colocalized with p62, a chaperone protein that binds to both aPKC and ubiquitin, in most of these inclusions. PKCι/λ also closely associated with the inactivated form of glycogen synthase kinase-3β, GSK-3β[ser9]. Together, these findings suggest that PKCι/λ may play a role in common mechanisms involving the pathogenesis of neurodegenerative disease." @default.
- W2000653725 created "2016-06-24" @default.
- W2000653725 creator A5019529442 @default.
- W2000653725 creator A5043503517 @default.
- W2000653725 creator A5062983762 @default.
- W2000653725 creator A5066548665 @default.
- W2000653725 creator A5086067249 @default.
- W2000653725 date "2006-04-01" @default.
- W2000653725 modified "2023-10-07" @default.
- W2000653725 title "Atypical Protein Kinase C in Neurodegenerative Disease II" @default.
- W2000653725 cites W1516372070 @default.
- W2000653725 cites W152096304 @default.
- W2000653725 cites W1532078866 @default.
- W2000653725 cites W154899493 @default.
- W2000653725 cites W1550876205 @default.
- W2000653725 cites W1564302359 @default.
- W2000653725 cites W1581358998 @default.
- W2000653725 cites W1584535802 @default.
- W2000653725 cites W1932252064 @default.
- W2000653725 cites W1972694157 @default.
- W2000653725 cites W1979153645 @default.
- W2000653725 cites W1988509015 @default.
- W2000653725 cites W1993968078 @default.
- W2000653725 cites W2003081257 @default.
- W2000653725 cites W2003179114 @default.
- W2000653725 cites W2006540590 @default.
- W2000653725 cites W2008462998 @default.
- W2000653725 cites W2008735323 @default.
- W2000653725 cites W2012311232 @default.
- W2000653725 cites W2019254928 @default.
- W2000653725 cites W2021736150 @default.
- W2000653725 cites W2031104034 @default.
- W2000653725 cites W2032095475 @default.
- W2000653725 cites W2034210468 @default.
- W2000653725 cites W2036745486 @default.
- W2000653725 cites W2039629489 @default.
- W2000653725 cites W2042739359 @default.
- W2000653725 cites W2058100973 @default.
- W2000653725 cites W2071243806 @default.
- W2000653725 cites W2071881564 @default.
- W2000653725 cites W2081460133 @default.
- W2000653725 cites W2090985642 @default.
- W2000653725 cites W2095436835 @default.
- W2000653725 cites W2098257571 @default.
- W2000653725 cites W2107472561 @default.
- W2000653725 cites W2110816024 @default.
- W2000653725 cites W2117223239 @default.
- W2000653725 cites W2123056519 @default.
- W2000653725 cites W2136800594 @default.
- W2000653725 cites W2146729934 @default.
- W2000653725 cites W2148569529 @default.
- W2000653725 cites W2151197773 @default.
- W2000653725 cites W2152506041 @default.
- W2000653725 cites W2159232889 @default.
- W2000653725 cites W2168224573 @default.
- W2000653725 cites W2328517878 @default.
- W2000653725 cites W69591616 @default.
- W2000653725 doi "https://doi.org/10.1097/01.jnen.0000218441.00040.82" @default.
- W2000653725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16691114" @default.
- W2000653725 hasPublicationYear "2006" @default.
- W2000653725 type Work @default.
- W2000653725 sameAs 2000653725 @default.
- W2000653725 citedByCount "41" @default.
- W2000653725 countsByYear W20006537252012 @default.
- W2000653725 countsByYear W20006537252013 @default.
- W2000653725 countsByYear W20006537252014 @default.
- W2000653725 countsByYear W20006537252018 @default.
- W2000653725 countsByYear W20006537252019 @default.
- W2000653725 countsByYear W20006537252020 @default.
- W2000653725 countsByYear W20006537252022 @default.
- W2000653725 countsByYear W20006537252023 @default.
- W2000653725 crossrefType "journal-article" @default.
- W2000653725 hasAuthorship W2000653725A5019529442 @default.
- W2000653725 hasAuthorship W2000653725A5043503517 @default.
- W2000653725 hasAuthorship W2000653725A5062983762 @default.
- W2000653725 hasAuthorship W2000653725A5066548665 @default.
- W2000653725 hasAuthorship W2000653725A5086067249 @default.
- W2000653725 hasBestOaLocation W20006537251 @default.
- W2000653725 hasConcept C142724271 @default.
- W2000653725 hasConcept C169760540 @default.
- W2000653725 hasConcept C182996813 @default.
- W2000653725 hasConcept C184235292 @default.
- W2000653725 hasConcept C195794163 @default.
- W2000653725 hasConcept C2776477761 @default.
- W2000653725 hasConcept C2776936178 @default.
- W2000653725 hasConcept C2777440831 @default.
- W2000653725 hasConcept C2778548049 @default.
- W2000653725 hasConcept C2778670691 @default.
- W2000653725 hasConcept C2779097696 @default.
- W2000653725 hasConcept C2779134260 @default.
- W2000653725 hasConcept C2779483572 @default.
- W2000653725 hasConcept C2779734285 @default.
- W2000653725 hasConcept C2781172350 @default.
- W2000653725 hasConcept C2781449126 @default.
- W2000653725 hasConcept C502032728 @default.
- W2000653725 hasConcept C71924100 @default.
- W2000653725 hasConcept C86803240 @default.
- W2000653725 hasConcept C95444343 @default.