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- W2000654941 abstract "Abstract Progesterone metabolism was studied in five pregnant women with intrahepatic cholestasis by determining several free and conjugated epimeric pregnanolones and pregnanediols and their 16α-and 21-hydroxylated derivatives in urine, bile and plasma. Comparison of the steroid profiles of these patients with those of healthy pregnant women showed the following features of intrahepatic cholestasis: (i) Biliary excretion of progesterone metabolites is impaired. 1. (ii) The conjugation of progesterone metabolites changes towards greater sulphate formation. 2. (iii) The metabolism of the steroid moiety of progesterone seems to differ from that occurring in normal pregnancy. These changes are in part attributable to the diminished enterohepatic circulation of steroids and in part to the increased steroid content of the liver cells." @default.
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- W2000654941 date "1973-11-01" @default.
- W2000654941 modified "2023-09-25" @default.
- W2000654941 title "Excretion of progesterone metabolites in urine and bile of pregnant women with intrahepatic cholestasis" @default.
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- W2000654941 doi "https://doi.org/10.1016/0022-4731(73)90039-3" @default.
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