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- W2000655394 abstract "Lambda) for the detection of HLAab in serum/plasma of 54 patients. 10/54 patients exhibited a positive ELISA post-LTx (ELISA ). 9 ELISA patients were in the ACSAgroup and one patient with preformed donor-specific HLAab received ACSA for 4 months. The HLAab pattern was: 2 patients had both class I and II HLAab, 3 class II and 5 class I. 2/10 of these patients tested ELISA pre-LTx. In 6/9 patients we were able to identify donor-specific HLAab. De novo HLAab were developed in 5/10 ELISA patients. In 9/10 of ELISA patients, the presence of HLAab was associated with a P/R during the first 18 months, comparatively with only 2/14 in the ELISA-/ACSA group (p 0.0003) and with 13/30 in ELISA-/ACSA(p 0.01). There was a tendency for fewer P/R in ACSA /ELISArelative to ACSA-/ ELISApatients (p 0.08). The frequency of HACR episodes in ELISA group was significantly higher than in ELISAgroup (28/83 versus 36/340, 2 27.84, p 0.00001). Furthermore, the ELISA patients required increased immunosuppression ( 2 course of bolus steroids and/or antilymphocytic agents-p 0.005). Conclusions: The presence of ELISA-detected HLAab positively correlated with increased risk of severe acute rejection. These LTx patients may benefit from an altered strategy of immunosuppression. LTx recipients in the ACSA protocol exhibited the lowest prevalence of P/R." @default.
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- W2000655394 date "2003-01-01" @default.
- W2000655394 modified "2023-09-27" @default.
- W2000655394 title "Vascular endothelial growth factor gene polymorphism are associated with acute rejection after heart transplantation" @default.
- W2000655394 doi "https://doi.org/10.1016/s1053-2498(02)00970-1" @default.
- W2000655394 hasPublicationYear "2003" @default.
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