Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000655752> ?p ?o ?g. }
- W2000655752 endingPage "4039" @default.
- W2000655752 startingPage "4029" @default.
- W2000655752 abstract "The nucleosome remodelling ATPase ISWI resides in several distinct protein complexes whose subunit composition reflects their functional specialization. Association of ISWI with ACF1, the largest subunit of CHRAC and ACF complexes, improves the efficiency of ISWI-induced nucleosome mobilization by an order of magnitude and also modulates the reaction qualitatively. In order to understand the principle by which ACF1 improves the efficiency of ISWI, we mapped their mutual interaction requirements and generated a series of ACF complexes lacking conserved ACF1 domains. Deletion of the C-terminal PHD finger modules of ACF1 or their disruption by zinc chelation profoundly affected the nucleosome mobilization capability of associated ISWI in trans. Interactions of the PHD fingers with the central domains of core histones contribute significantly to the binding of ACF to the nucleosome substrate, suggesting a novel role for PHD modules as nucleosome interaction determinants. Connecting ACF to histones may be prerequisite for efficient conversion of ATP-dependent conformational changes of ISWI into translocation of DNA relative to the histones during nucleosome mobilization." @default.
- W2000655752 created "2016-06-24" @default.
- W2000655752 creator A5017085468 @default.
- W2000655752 creator A5031603729 @default.
- W2000655752 creator A5034032941 @default.
- W2000655752 creator A5073693959 @default.
- W2000655752 date "2004-09-30" @default.
- W2000655752 modified "2023-09-23" @default.
- W2000655752 title "ACF1 improves the effectiveness of nucleosome mobilization by ISWI through PHD–histone contacts" @default.
- W2000655752 cites W1557877833 @default.
- W2000655752 cites W1593240978 @default.
- W2000655752 cites W1766348042 @default.
- W2000655752 cites W1832882893 @default.
- W2000655752 cites W1938386297 @default.
- W2000655752 cites W1964318436 @default.
- W2000655752 cites W1967291882 @default.
- W2000655752 cites W1973672022 @default.
- W2000655752 cites W1988754209 @default.
- W2000655752 cites W1989325752 @default.
- W2000655752 cites W1990586926 @default.
- W2000655752 cites W1991442937 @default.
- W2000655752 cites W1991556982 @default.
- W2000655752 cites W2002167083 @default.
- W2000655752 cites W2002488318 @default.
- W2000655752 cites W2004705005 @default.
- W2000655752 cites W2006591674 @default.
- W2000655752 cites W2010108246 @default.
- W2000655752 cites W2011789977 @default.
- W2000655752 cites W2012317303 @default.
- W2000655752 cites W2016730661 @default.
- W2000655752 cites W2021487219 @default.
- W2000655752 cites W2030851477 @default.
- W2000655752 cites W2042576491 @default.
- W2000655752 cites W2044495919 @default.
- W2000655752 cites W2053524547 @default.
- W2000655752 cites W2082819099 @default.
- W2000655752 cites W2085299836 @default.
- W2000655752 cites W2085584897 @default.
- W2000655752 cites W2085694012 @default.
- W2000655752 cites W2092797711 @default.
- W2000655752 cites W2093397699 @default.
- W2000655752 cites W2096596194 @default.
- W2000655752 cites W2098589211 @default.
- W2000655752 cites W2100285856 @default.
- W2000655752 cites W2103693964 @default.
- W2000655752 cites W2104571078 @default.
- W2000655752 cites W2108385007 @default.
- W2000655752 cites W2126824096 @default.
- W2000655752 cites W2129378146 @default.
- W2000655752 cites W2136796186 @default.
- W2000655752 cites W2143658931 @default.
- W2000655752 cites W2144484738 @default.
- W2000655752 cites W2147009113 @default.
- W2000655752 cites W2153612581 @default.
- W2000655752 cites W2162811733 @default.
- W2000655752 cites W2169333252 @default.
- W2000655752 cites W2171849558 @default.
- W2000655752 cites W2177578477 @default.
- W2000655752 cites W2739174192 @default.
- W2000655752 doi "https://doi.org/10.1038/sj.emboj.7600382" @default.
- W2000655752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/524333" @default.
- W2000655752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15457208" @default.
- W2000655752 hasPublicationYear "2004" @default.
- W2000655752 type Work @default.
- W2000655752 sameAs 2000655752 @default.
- W2000655752 citedByCount "103" @default.
- W2000655752 countsByYear W20006557522012 @default.
- W2000655752 countsByYear W20006557522013 @default.
- W2000655752 countsByYear W20006557522014 @default.
- W2000655752 countsByYear W20006557522015 @default.
- W2000655752 countsByYear W20006557522016 @default.
- W2000655752 countsByYear W20006557522017 @default.
- W2000655752 countsByYear W20006557522018 @default.
- W2000655752 countsByYear W20006557522020 @default.
- W2000655752 countsByYear W20006557522021 @default.
- W2000655752 crossrefType "journal-article" @default.
- W2000655752 hasAuthorship W2000655752A5017085468 @default.
- W2000655752 hasAuthorship W2000655752A5031603729 @default.
- W2000655752 hasAuthorship W2000655752A5034032941 @default.
- W2000655752 hasAuthorship W2000655752A5073693959 @default.
- W2000655752 hasBestOaLocation W20006557521 @default.
- W2000655752 hasConcept C104292427 @default.
- W2000655752 hasConcept C104317684 @default.
- W2000655752 hasConcept C12554922 @default.
- W2000655752 hasConcept C166941617 @default.
- W2000655752 hasConcept C24284526 @default.
- W2000655752 hasConcept C54355233 @default.
- W2000655752 hasConcept C552990157 @default.
- W2000655752 hasConcept C64927066 @default.
- W2000655752 hasConcept C84772758 @default.
- W2000655752 hasConcept C86339819 @default.
- W2000655752 hasConcept C86803240 @default.
- W2000655752 hasConcept C95444343 @default.
- W2000655752 hasConceptScore W2000655752C104292427 @default.
- W2000655752 hasConceptScore W2000655752C104317684 @default.
- W2000655752 hasConceptScore W2000655752C12554922 @default.
- W2000655752 hasConceptScore W2000655752C166941617 @default.
- W2000655752 hasConceptScore W2000655752C24284526 @default.