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- W2000656713 abstract "A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of tramadol and its major metabolites O-demethyltramadol and N-demethyltramadol in urine has been developed. The determination of the enantiomeric ratios of the three compounds was achieved using a Chiralpak AD column and a Chiralcel OD column, respectively. After oral administration of racemic tramadol to five healthy volunteers, inter-individual differences of the excreted amounts and the enantiomeric ratios of the compounds were observed." @default.
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- W2000656713 date "1993-02-01" @default.
- W2000656713 modified "2023-09-27" @default.
- W2000656713 title "Achiral and chiral high-performance liquid chromatographic determination of tramadol and its major metabolites in urine after oral administration of racemic tramadol" @default.
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- W2000656713 doi "https://doi.org/10.1016/0378-4347(93)80167-3" @default.
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