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• W2000656893 abstract "The two stimulatory G protein alpha subunits, Galphas and Galphaolf, activate adenylyl cyclase in a similar way. We examined whether type 5 adenylyl cyclase knockout, the major striatal isoform, can differentially and/or developmentally change the expression of these G proteins in the striatum. Galphas and Galphaolf expressions at birth were unaffected in knockouts, which, however, demonstrated a blunted developmental increase in Galphaolf, but not Galphas. Adenylyl cyclase activity was unaffected at birth, but subsequently became lower in knockouts. These findings suggest that type 5 adenylyl cyclase does not contribute to striatal cAMP signaling at birth. However, it may play an important role in developmental changes in the expression of Galphaolf, but not Galphas." @default.
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• W2000656893 date "2004-03-26" @default.
• W2000656893 modified "2023-09-26" @default.
• W2000656893 title "Disruption of type 5 adenylyl cyclase negates the developmental increase in Gαolf expression in the striatum" @default.
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• W2000656893 doi "https://doi.org/10.1016/s0014-5793(04)00333-3" @default.
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