Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000657219> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2000657219 endingPage "1459" @default.
- W2000657219 startingPage "1455" @default.
- W2000657219 abstract "The effect of clofibrate, a hypolipidemic drug and also known as a peroxisomal proliferator, on the conversion ratio of tryptophan to niacin was investigated by using rats. The rats were fed with a nicotinic acid-free, 20% casein diet (control group) or the same diet + 0.25% clofibrate group) for 19 days. The conversion ratio gradually increased with increasing number of days. Around day 8, the ratio was about 10-times higher in the clofibrate group than in the control group, and the value remained almost constant after that day. The content of liver total nicotinamide was higher in the clofibrate group than in the control group. Among the enzymes involved in the conversion of tryptophan to niacin, the aminocarboxymuconate-semialdehyde decarboxylase (ACMSDase) activity, which is critical in the conversion, was lower in the clofibrate group than in the control group. As the change in ACMSDase activity took several days, there is a possibility that clofibrate decreased the biosynthesis of ACMSDase protein and/or mRNA. To learn whether the increase in the conversion ratio by clofibrate would be nutritionally meaningful or not, the growth-promoting activity of clofibrate was determined by using weanling rats fed with a nicotinic acid-free, tryptophan-limiting diet (basal diet). As a result, the body weight gain was higher in the clofibrate group than in the basal group. This result shows that clofibrate enhanced the conversion ratio without any side-effects under the conditions used and supports again the claim that the activity of ACMSDase exerts a critical influence on the tryptophan-NAD conversion." @default.
- W2000657219 created "2016-06-24" @default.
- W2000657219 creator A5009397734 @default.
- W2000657219 creator A5038029943 @default.
- W2000657219 creator A5039637864 @default.
- W2000657219 creator A5071574027 @default.
- W2000657219 date "1996-01-01" @default.
- W2000657219 modified "2023-09-23" @default.
- W2000657219 title "Increased Conversion Ratio of Tryptophan to Niacin by the Administration of Clofibrate, a Hypolipidemic Drug, to Rats" @default.
- W2000657219 doi "https://doi.org/10.1271/bbb.60.1455" @default.
- W2000657219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8987594" @default.
- W2000657219 hasPublicationYear "1996" @default.
- W2000657219 type Work @default.
- W2000657219 sameAs 2000657219 @default.
- W2000657219 citedByCount "22" @default.
- W2000657219 countsByYear W20006572192012 @default.
- W2000657219 countsByYear W20006572192013 @default.
- W2000657219 countsByYear W20006572192015 @default.
- W2000657219 countsByYear W20006572192016 @default.
- W2000657219 countsByYear W20006572192018 @default.
- W2000657219 countsByYear W20006572192022 @default.
- W2000657219 crossrefType "journal-article" @default.
- W2000657219 hasAuthorship W2000657219A5009397734 @default.
- W2000657219 hasAuthorship W2000657219A5038029943 @default.
- W2000657219 hasAuthorship W2000657219A5039637864 @default.
- W2000657219 hasAuthorship W2000657219A5071574027 @default.
- W2000657219 hasBestOaLocation W20006572191 @default.
- W2000657219 hasConcept C126322002 @default.
- W2000657219 hasConcept C134018914 @default.
- W2000657219 hasConcept C181199279 @default.
- W2000657219 hasConcept C185592680 @default.
- W2000657219 hasConcept C2776706248 @default.
- W2000657219 hasConcept C2778024521 @default.
- W2000657219 hasConcept C2779306644 @default.
- W2000657219 hasConcept C2779496979 @default.
- W2000657219 hasConcept C2779728014 @default.
- W2000657219 hasConcept C2780092750 @default.
- W2000657219 hasConcept C515207424 @default.
- W2000657219 hasConcept C55493867 @default.
- W2000657219 hasConcept C71924100 @default.
- W2000657219 hasConcept C86803240 @default.
- W2000657219 hasConceptScore W2000657219C126322002 @default.
- W2000657219 hasConceptScore W2000657219C134018914 @default.
- W2000657219 hasConceptScore W2000657219C181199279 @default.
- W2000657219 hasConceptScore W2000657219C185592680 @default.
- W2000657219 hasConceptScore W2000657219C2776706248 @default.
- W2000657219 hasConceptScore W2000657219C2778024521 @default.
- W2000657219 hasConceptScore W2000657219C2779306644 @default.
- W2000657219 hasConceptScore W2000657219C2779496979 @default.
- W2000657219 hasConceptScore W2000657219C2779728014 @default.
- W2000657219 hasConceptScore W2000657219C2780092750 @default.
- W2000657219 hasConceptScore W2000657219C515207424 @default.
- W2000657219 hasConceptScore W2000657219C55493867 @default.
- W2000657219 hasConceptScore W2000657219C71924100 @default.
- W2000657219 hasConceptScore W2000657219C86803240 @default.
- W2000657219 hasIssue "9" @default.
- W2000657219 hasLocation W20006572191 @default.
- W2000657219 hasLocation W20006572192 @default.
- W2000657219 hasOpenAccess W2000657219 @default.
- W2000657219 hasPrimaryLocation W20006572191 @default.
- W2000657219 hasRelatedWork W1998913035 @default.
- W2000657219 hasRelatedWork W2015703171 @default.
- W2000657219 hasRelatedWork W2030320197 @default.
- W2000657219 hasRelatedWork W2077325982 @default.
- W2000657219 hasRelatedWork W2162653391 @default.
- W2000657219 hasRelatedWork W2208307236 @default.
- W2000657219 hasRelatedWork W2316695362 @default.
- W2000657219 hasRelatedWork W2325971639 @default.
- W2000657219 hasRelatedWork W2327764008 @default.
- W2000657219 hasRelatedWork W1663626435 @default.
- W2000657219 hasVolume "60" @default.
- W2000657219 isParatext "false" @default.
- W2000657219 isRetracted "false" @default.
- W2000657219 magId "2000657219" @default.
- W2000657219 workType "article" @default.