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- W2000657673 abstract "The 11-deoxyprostaglandin analogue 15(nat)-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acid (AY-24,609) was found to be an effective inhibitor of gastric acid secretion and ulcer formation when administered orally in the rat. In comparison with the structurally-related 15-hydroxy-15-methyl-9-oxoprostanoic acid (AY-22,469), AY-24,609 was more potent with respect to the following activities:Inhibition of basal gastric acid secretion (Shay), 8.7 times;ulcer formation induced by pylorus ligation (19-hour Shay), 9.0 times;ulcer formation induced by indomethacin, 4.8 times. Inhibition of basal gastric acid secretion (Shay), 8.7 times; ulcer formation induced by pylorus ligation (19-hour Shay), 9.0 times; ulcer formation induced by indomethacin, 4.8 times. The ED50 for causing diarrhea in the 24-hour starved rat was 7 mg/kg for AY-24,609 and 140 mg/kg for AY-22,469. The other stereoisomer at C-15 of the 16,16-dimethyl analogue, i.e. the 15(epi) analogue (AY-24,696), was less active than AY-24,609 with the above relative activities in comparison to AY-22,469 being 0.6, 1.6 and 2.5, respectively. The ED50 for producing diarrheas was 49 mg/kg. AY-24,609 and AY-22,469 did not generally alter the gastric juice volume. AY-24,609, as AY-22,469, appears to be a potentially useful therapeutic agent for the treatment of hypergastric acid secretion and peptic ulcers." @default.
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- W2000657673 title "Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids" @default.
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- W2000657673 doi "https://doi.org/10.1016/0090-6980(74)90007-0" @default.
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