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- W2000658230 abstract "This study was designed to test in experimental animals the hypothesis (Renwick, 1972) that human spina bifida and anencephalus are causally related to maternal consumption of blighted potatoes. Gavaging of pregnant rats with blighted potatoes on days 5–11 or daily ip injections of solanine or glycoalkaloids (5–10 mg/kg) extracted from B5141-6 potatoes, given on days 5–12 or 7–17 of gestation, resuited in minor skeletal and renal tract abnormalities, but failed to produce neural-tube defects. Daily injections (days 5–12) of 20 and 40 mg/kg of the glycoalkaloid caused 100% fetal and maternal mortality, respectively. Daily ip injections of 5 mg/kg of solanine into New Zealand White rabbits on days 0–8 of gestation produced abortion in one-third of the treated animals, 23% resorptions, but no teratogenesis. Single yolk-sac injections of 5–20 mg/kg of solanine into 20–22 h incubated white Leghorn eggs produced 63–90% mortality within 72 h without significant teratogenesis. Diced B5141-6 potatoes containing an average of 260 mg of solanine per kg of tuber fed ad libitum to time-mated rhesus monkeys for a period of 25 days postcopulation produced no maternal toxicity; on the other hand single injections of 40 mg/kg of the glycoalkaloid extract and two injections of 20 mg/kg of solanine killed adults within 48 h of treatment. At autopsy nasal, oral, and periorbital hemorrhage was present; there was accumulation of serosanguinous pleural and peritoneal fluids and mild hepatic and splenic congestion. Examples of human toxicity and mortality from consuming potatoes with a high solanine content are reviewed." @default.
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- W2000658230 date "1973-12-01" @default.
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- W2000658230 title "Are potatoes teratogenic for experimental animals?" @default.
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- W2000658230 doi "https://doi.org/10.1002/tera.1420080318" @default.
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