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- W2000658239 abstract "Nanoparticles are finding increased uses in drug delivery applications as a means to increase treatment efficacy and improve patient care. Here, we report engineered polymeric nanoparticles that undergo a hydrophobic to hydrophilic transition at pH 5 to afford swelling and rapid release of their contents. As our clinical interest lies in the prevention of lung tumor recurrence following resection, the nanoparticles were evaluated in a model mimicking microscopic disease, akin to residual occult tumor that can remain at the resection margin following surgery. Expansile nanoparticles loaded with paclitaxel, a poorly water-soluble anticancer drug, prevent establishment of lung cancer in vivo and are superior to the conventional drug delivery method for paclitaxel using Cremophor EL/ethanol." @default.
- W2000658239 created "2016-06-24" @default.
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- W2000658239 date "2009-01-30" @default.
- W2000658239 modified "2023-10-17" @default.
- W2000658239 title "Expansile Nanoparticles: Synthesis, Characterization, and <i>in Vivo</i> Efficacy of an Acid-Responsive Polymeric Drug Delivery System" @default.
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- W2000658239 doi "https://doi.org/10.1021/ja807416t" @default.
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