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- W2000658882 abstract "Idiopathic dilated cardiomyopathy (IDC) is a heterogenous group of disorders united by the findings of a dilated and poorly contractile left ventricle and normal coronary arteries. 1 Chen S.-C Nouri S Balfour I Jureidini S Appleton R.S Clinical profile of congestive cardiomyopathy in children. J Am Coll Cardiol. 1990; 15: 189-193 Abstract Full Text PDF PubMed Scopus (85) Google Scholar , 2 Matitiau A Perez-Atayde A Sanders S.P Sluysmans T Parness I.A Spevak P.J Colan S.D Infantile dilated cardiomyopathy relation of outcome to left ventricular mechanics, hemodynamics and histology at the time of presentation. Circulation. 1994; 90: 1310-1318 Crossref PubMed Scopus (122) Google Scholar Electrocardiographic changes suggesting myocardial infarction have been documented in children with IDC. In addition, histologic findings of subendocardial fibroelastosis and scarring, suggestive of long lasting myocardial ischemia, have been observed despite normal coronary arteries. 1 Chen S.-C Nouri S Balfour I Jureidini S Appleton R.S Clinical profile of congestive cardiomyopathy in children. J Am Coll Cardiol. 1990; 15: 189-193 Abstract Full Text PDF PubMed Scopus (85) Google Scholar , 2 Matitiau A Perez-Atayde A Sanders S.P Sluysmans T Parness I.A Spevak P.J Colan S.D Infantile dilated cardiomyopathy relation of outcome to left ventricular mechanics, hemodynamics and histology at the time of presentation. Circulation. 1994; 90: 1310-1318 Crossref PubMed Scopus (122) Google Scholar It has been hypothesized that impaired myocardial blood flow, both at rest and during conditions of increased myocardial oxygen demand, may play a potential role in the pathogenesis and progression of the left ventricular (LV) dysfunction observed in IDC. 3 Pasternac A Noble J Streulens Y Elie R Henschke C Bourassa M.G Pathophysiology of chest pain in patients with cardiomyopathies and normal coronary arteries. Circulation. 1982; 65: 778-789 Crossref PubMed Scopus (188) Google Scholar , 4 Neglia D Parodi O Gallopin M Sambuceti G Giorgetti A Pratali L Salvadori P Michelassi C Lunardi M Pelosi G Marzilli M.L.’ Abbate A Myocardial blood flow response to pacing tachycardia and of dipyridamole infusion in patients with dilated cardiomyopathy without overt heart failure. A quantitive assessment by positron emission tomography. Circulation. 1995; 92: 796-804 Crossref PubMed Scopus (179) Google Scholar , 5 van den Heuvel A.F van Veldhuisen D.J van der Wall E.E Blanksma P.K Siebelink H.M Vaalburg W.M van Gilst W.H Crijns H.J Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with dilated cardiomyopathy. J Am Coll Cardiol. 2000; 35: 19-28 Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar Coronary flow studies in children with IDC are entirely lacking, whereas studies of coronary flow at rest in adults with IDC have shown conflicting results of either normal or reduced perfusion. 3 Pasternac A Noble J Streulens Y Elie R Henschke C Bourassa M.G Pathophysiology of chest pain in patients with cardiomyopathies and normal coronary arteries. Circulation. 1982; 65: 778-789 Crossref PubMed Scopus (188) Google Scholar , 4 Neglia D Parodi O Gallopin M Sambuceti G Giorgetti A Pratali L Salvadori P Michelassi C Lunardi M Pelosi G Marzilli M.L.’ Abbate A Myocardial blood flow response to pacing tachycardia and of dipyridamole infusion in patients with dilated cardiomyopathy without overt heart failure. A quantitive assessment by positron emission tomography. Circulation. 1995; 92: 796-804 Crossref PubMed Scopus (179) Google Scholar , 5 van den Heuvel A.F van Veldhuisen D.J van der Wall E.E Blanksma P.K Siebelink H.M Vaalburg W.M van Gilst W.H Crijns H.J Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with dilated cardiomyopathy. J Am Coll Cardiol. 2000; 35: 19-28 Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar , 6 Mathier M.A Rose G.A Fifer M.A Miyamoto M.I Dinsmore R.E Castano H.H Dec G.W Palacios I.F Semigran M.J Coronary endothelial dysfunction in patients with acute-onset idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 1998; 32: 216-224 Abstract Full Text Full Text PDF PubMed Scopus (77) Google Scholar , 7 Weiss M.B Ellis K Sciacca R.R Johnson L.L Schmidt D.H Cannon P.J Myocardial blood flow in congestive and hypertrophic cardiomyopathy. Relationship to peak wall stress and mean velocity of circumferential fiber shortening. Circulation. 1976; 54: 484-494 Crossref PubMed Scopus (106) Google Scholar , 8 Chati Z Bruntz J.F Ethévenot G Aliot E Zannad F Abnormal transoesophageal Doppler coronary flow reserve in patients with dilated cardiomyopathy relationship to exercise capacity. Clin Sci. 1998; 94: 485-492 PubMed Google Scholar Transthoracic echocardiography with Doppler has recently been introduced as a valuable tool in the assessment of coronary flow in children. 9 Jureidini S.B Marino C.J Waterman B Syamasundar R.P Balfour I.C Chen S Nouri S Transthoracic Doppler echocardiography of normally originating coronary arteries in children. J Am Soc Echocardiogr. 1998; 11: 409-420 Abstract Full Text Full Text PDF PubMed Scopus (33) Google Scholar This study was designed to evaluate resting left coronary flow in infants with recently diagnosed IDC, using transthoracic echocardiography and Doppler." @default.
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- W2000658882 title "Flow dynamics in the left anterior descending coronary artery in infants with idiopathic dilated cardiomyopathy" @default.
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