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- W2000659418 abstract "The need for potentiating immune responses to recombinant or subunit antigens has prompted GlaxoSmithKline (GSK) Biologicals to develop various Adjuvant Systems for the design of prophylactic and therapeutic vaccines. Adjuvant Systems are formulations of classical adjuvants mixed with immunomodulators, specifically adapted to the antigen and the target population. They can activate the appropriate innate immune system and subsequently impact on adaptive immune responses. AS04 is an Adjuvant System that has demonstrated significant achievements in several vaccines against viral diseases. AS02, another Adjuvant System, is being evaluated in various contexts, where a strong T-cell response is needed to afford protection. Likewise, AS01 has been developed for vaccines where the induction of a yet stronger T-cell-mediated immune response is required. Altogether, the promising clinical results strongly support the concept of Adjuvant Systems and allow for further development of new vaccines, best adapted to the target population and the immune mechanisms of protection." @default.
- W2000659418 created "2016-06-24" @default.
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- W2000659418 creator A5029032645 @default.
- W2000659418 creator A5051008333 @default.
- W2000659418 date "2007-10-01" @default.
- W2000659418 modified "2023-10-16" @default.
- W2000659418 title "GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectives" @default.
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- W2000659418 doi "https://doi.org/10.1586/14760584.6.5.723" @default.
- W2000659418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17931153" @default.
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