FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000660225> ?p ?o ?g. }

• W2000660225 endingPage "200" @default.
• W2000660225 startingPage "193" @default.
• W2000660225 abstract "Primary human immunodeficiency virus type 2 (HIV-2) isolates are characterized by their ability to use a broad range of coreceptors, including CCR5, CXCR4, and several alternative coreceptors. However, the in vivo relevance of this in vitro promiscuity in coreceptor usage remains unclear. We set out to evaluate the relative importance of CCR5 and CXCR4 for infection of activated peripheral blood mononuclear cells (PBMC). PBMC from donors homozygous for wild-type CCR5 (CCR5(+/+) or CCR5Delta32 (CCR5(-/-)) were tested for their susceptibility to infection with 10 primary HIV-2 isolates with known coreceptor usage by parallel 50% tissue culture infectious dose (TCID50) titrations. Although all isolates, except one, were able to establish productive infection in CCR5(-/-) PBMC, the infection of these cells was inefficient for all isolates that were unable to use CXCR4. For CXCR4-using isolates there were only minor differences in TCID50 between CCR5(+/+) and CCR5(-/-) PBMC. When we compared the replication kinetics in PBMC from donors of the two genotypes we observed an average delay in replication onset of 9 days in the CCR5(-/-) PBMC. This study shows that HIV-2 can use alternative coreceptors for infection of PBMC, but that this infection is much less efficient than infection mediated by CCR5 or CXCR4. Thus, CCR5 and CXCR4 appear to be the major coreceptors for HIV-2 infection of PBMC." @default.
• W2000660225 created "2016-06-24" @default.
• W2000660225 creator A5001201292 @default.
• W2000660225 creator A5017013855 @default.
• W2000660225 creator A5018442049 @default.
• W2000660225 creator A5036531520 @default.
• W2000660225 creator A5058665704 @default.
• W2000660225 creator A5061200353 @default.
• W2000660225 date "2002-02-10" @default.
• W2000660225 modified "2023-10-17" @default.
• W2000660225 title "CCR5 or CXCR4 Is Required for Efficient Infection of Peripheral Blood Mononuclear Cells by Promiscuous Human Immunodeficiency Virus Type 2 Primary Isolates" @default.
• W2000660225 cites W1623426438 @default.
• W2000660225 cites W1973684423 @default.
• W2000660225 cites W1978201079 @default.
• W2000660225 cites W1981422768 @default.
• W2000660225 cites W1983466424 @default.
• W2000660225 cites W1985697281 @default.
• W2000660225 cites W2001190262 @default.
• W2000660225 cites W2011103103 @default.
• W2000660225 cites W2026444780 @default.
• W2000660225 cites W2028013252 @default.
• W2000660225 cites W2052787424 @default.
• W2000660225 cites W2056360005 @default.
• W2000660225 cites W2063023106 @default.
• W2000660225 cites W2066163381 @default.
• W2000660225 cites W2090630729 @default.
• W2000660225 cites W2097183306 @default.
• W2000660225 cites W2117050139 @default.
• W2000660225 cites W2124193326 @default.
• W2000660225 cites W2124846613 @default.
• W2000660225 cites W2128031350 @default.
• W2000660225 cites W2146226401 @default.
• W2000660225 cites W2156694786 @default.
• W2000660225 cites W2158850631 @default.
• W2000660225 cites W2165866576 @default.
• W2000660225 cites W2168350557 @default.
• W2000660225 cites W2234512883 @default.
• W2000660225 doi "https://doi.org/10.1089/08892220252781248" @default.
• W2000660225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11839153" @default.
• W2000660225 hasPublicationYear "2002" @default.
• W2000660225 type Work @default.
• W2000660225 sameAs 2000660225 @default.
• W2000660225 citedByCount "20" @default.
• W2000660225 countsByYear W20006602252012 @default.
• W2000660225 countsByYear W20006602252013 @default.
• W2000660225 countsByYear W20006602252015 @default.
• W2000660225 countsByYear W20006602252016 @default.
• W2000660225 countsByYear W20006602252021 @default.
• W2000660225 countsByYear W20006602252022 @default.
• W2000660225 crossrefType "journal-article" @default.
• W2000660225 hasAuthorship W2000660225A5001201292 @default.
• W2000660225 hasAuthorship W2000660225A5017013855 @default.
• W2000660225 hasAuthorship W2000660225A5018442049 @default.
• W2000660225 hasAuthorship W2000660225A5036531520 @default.
• W2000660225 hasAuthorship W2000660225A5058665704 @default.
• W2000660225 hasAuthorship W2000660225A5061200353 @default.
• W2000660225 hasConcept C129470790 @default.
• W2000660225 hasConcept C13373296 @default.
• W2000660225 hasConcept C134040284 @default.
• W2000660225 hasConcept C137061746 @default.
• W2000660225 hasConcept C140704245 @default.
• W2000660225 hasConcept C159047783 @default.
• W2000660225 hasConcept C202751555 @default.
• W2000660225 hasConcept C203014093 @default.
• W2000660225 hasConcept C2522874641 @default.
• W2000660225 hasConcept C2779690655 @default.
• W2000660225 hasConcept C2780727368 @default.
• W2000660225 hasConcept C54355233 @default.
• W2000660225 hasConcept C86803240 @default.
• W2000660225 hasConcept C8891405 @default.
• W2000660225 hasConceptScore W2000660225C129470790 @default.
• W2000660225 hasConceptScore W2000660225C13373296 @default.
• W2000660225 hasConceptScore W2000660225C134040284 @default.
• W2000660225 hasConceptScore W2000660225C137061746 @default.
• W2000660225 hasConceptScore W2000660225C140704245 @default.
• W2000660225 hasConceptScore W2000660225C159047783 @default.
• W2000660225 hasConceptScore W2000660225C202751555 @default.
• W2000660225 hasConceptScore W2000660225C203014093 @default.
• W2000660225 hasConceptScore W2000660225C2522874641 @default.
• W2000660225 hasConceptScore W2000660225C2779690655 @default.
• W2000660225 hasConceptScore W2000660225C2780727368 @default.
• W2000660225 hasConceptScore W2000660225C54355233 @default.
• W2000660225 hasConceptScore W2000660225C86803240 @default.
• W2000660225 hasConceptScore W2000660225C8891405 @default.
• W2000660225 hasIssue "3" @default.
• W2000660225 hasLocation W20006602251 @default.
• W2000660225 hasLocation W20006602252 @default.
• W2000660225 hasOpenAccess W2000660225 @default.
• W2000660225 hasPrimaryLocation W20006602251 @default.
• W2000660225 hasRelatedWork W1608862421 @default.
• W2000660225 hasRelatedWork W1825162875 @default.
• W2000660225 hasRelatedWork W1976695098 @default.
• W2000660225 hasRelatedWork W2000660225 @default.
• W2000660225 hasRelatedWork W2009671413 @default.
• W2000660225 hasRelatedWork W2078688899 @default.
• W2000660225 hasRelatedWork W2121098802 @default.
• W2000660225 hasRelatedWork W2126152546 @default.
• W2000660225 hasRelatedWork W2313414779 @default.

• next