FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000660448> ?p ?o ?g. }

• W2000660448 endingPage "885" @default.
• W2000660448 startingPage "880" @default.
• W2000660448 abstract "BackgroundNuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent transcription factor responsible for the regulation of xenobiotic, steroid, and bile acid metabolism. The ligand-binding domain is principally responsible for species-specific activation of NR1I2 in response to xenobiotic exposure.ObjectivesOur objective in this study was to create a common framework for screening NR1I2 orthologs from a variety of model species against environmentally relevant xenobiotics and to evaluate the results in light of using these species as predictors of xenobiotic disposition and for assessment of environmental health risk.MethodsSixteen chimeric fusion plasmid vectors expressing the Gal4 DNA-binding domain and species-specific NR1I2 ligand-binding domain were screened for activation against a spectrum of 27 xenobiotic compounds using a standardized cotransfection receptor activation assay.ResultsNR1I2 orthologs were activated by various ligands in a dose-dependent manner. Closely related species show broadly similar patterns of activation; however, considerable variation to individual compounds exists, even among species varying in only a few amino acid residues.ConclusionsInterspecies variation in NR1I2 activation by various ligands can be screened through the use of in vitro NR1I2 activation assays and should be taken into account when choosing appropriate animal models for assessing environmental health risk." @default.
• W2000660448 created "2016-06-24" @default.
• W2000660448 creator A5004211937 @default.
• W2000660448 creator A5005360431 @default.
• W2000660448 creator A5005879454 @default.
• W2000660448 creator A5019107328 @default.
• W2000660448 creator A5022592954 @default.
• W2000660448 creator A5044811616 @default.
• W2000660448 creator A5050915728 @default.
• W2000660448 creator A5055464257 @default.
• W2000660448 creator A5064346698 @default.
• W2000660448 creator A5083368895 @default.
• W2000660448 creator A5091521664 @default.
• W2000660448 date "2008-07-01" @default.
• W2000660448 modified "2023-10-18" @default.
• W2000660448 title "Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and Its Orthologs in Laboratory, Toxicologic, and Genome Model Species" @default.
• W2000660448 cites W1974909111 @default.
• W2000660448 cites W1981219795 @default.
• W2000660448 cites W1981873124 @default.
• W2000660448 cites W1986746415 @default.
• W2000660448 cites W1992250421 @default.
• W2000660448 cites W1993833615 @default.
• W2000660448 cites W2000581994 @default.
• W2000660448 cites W2001465268 @default.
• W2000660448 cites W2004401987 @default.
• W2000660448 cites W2032693719 @default.
• W2000660448 cites W2035000881 @default.
• W2000660448 cites W2051746949 @default.
• W2000660448 cites W2059316380 @default.
• W2000660448 cites W2066636198 @default.
• W2000660448 cites W2084462922 @default.
• W2000660448 cites W2092190477 @default.
• W2000660448 cites W2097382368 @default.
• W2000660448 cites W2109385821 @default.
• W2000660448 cites W2115541046 @default.
• W2000660448 cites W2117384395 @default.
• W2000660448 cites W2124476359 @default.
• W2000660448 cites W2131839319 @default.
• W2000660448 cites W2133677309 @default.
• W2000660448 cites W2136799713 @default.
• W2000660448 cites W2143301135 @default.
• W2000660448 cites W2148580475 @default.
• W2000660448 cites W2155882942 @default.
• W2000660448 cites W2157906581 @default.
• W2000660448 cites W2161816485 @default.
• W2000660448 cites W4210952832 @default.
• W2000660448 doi "https://doi.org/10.1289/ehp.10853" @default.
• W2000660448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2453155" @default.
• W2000660448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18629309" @default.
• W2000660448 hasPublicationYear "2008" @default.
• W2000660448 type Work @default.
• W2000660448 sameAs 2000660448 @default.
• W2000660448 citedByCount "51" @default.
• W2000660448 countsByYear W20006604482012 @default.
• W2000660448 countsByYear W20006604482013 @default.
• W2000660448 countsByYear W20006604482014 @default.
• W2000660448 countsByYear W20006604482015 @default.
• W2000660448 countsByYear W20006604482016 @default.
• W2000660448 countsByYear W20006604482017 @default.
• W2000660448 countsByYear W20006604482018 @default.
• W2000660448 countsByYear W20006604482019 @default.
• W2000660448 countsByYear W20006604482021 @default.
• W2000660448 countsByYear W20006604482022 @default.
• W2000660448 countsByYear W20006604482023 @default.
• W2000660448 crossrefType "journal-article" @default.
• W2000660448 hasAuthorship W2000660448A5004211937 @default.
• W2000660448 hasAuthorship W2000660448A5005360431 @default.
• W2000660448 hasAuthorship W2000660448A5005879454 @default.
• W2000660448 hasAuthorship W2000660448A5019107328 @default.
• W2000660448 hasAuthorship W2000660448A5022592954 @default.
• W2000660448 hasAuthorship W2000660448A5044811616 @default.
• W2000660448 hasAuthorship W2000660448A5050915728 @default.
• W2000660448 hasAuthorship W2000660448A5055464257 @default.
• W2000660448 hasAuthorship W2000660448A5064346698 @default.
• W2000660448 hasAuthorship W2000660448A5083368895 @default.
• W2000660448 hasAuthorship W2000660448A5091521664 @default.
• W2000660448 hasBestOaLocation W20006604481 @default.
• W2000660448 hasConcept C104317684 @default.
• W2000660448 hasConcept C115448650 @default.
• W2000660448 hasConcept C132040763 @default.
• W2000660448 hasConcept C170493617 @default.
• W2000660448 hasConcept C181199279 @default.
• W2000660448 hasConcept C185592680 @default.
• W2000660448 hasConcept C2780902042 @default.
• W2000660448 hasConcept C54355233 @default.
• W2000660448 hasConcept C55493867 @default.
• W2000660448 hasConcept C63932345 @default.
• W2000660448 hasConcept C70721500 @default.
• W2000660448 hasConcept C71315377 @default.
• W2000660448 hasConcept C86339819 @default.
• W2000660448 hasConcept C86803240 @default.
• W2000660448 hasConceptScore W2000660448C104317684 @default.
• W2000660448 hasConceptScore W2000660448C115448650 @default.
• W2000660448 hasConceptScore W2000660448C132040763 @default.
• W2000660448 hasConceptScore W2000660448C170493617 @default.
• W2000660448 hasConceptScore W2000660448C181199279 @default.
• W2000660448 hasConceptScore W2000660448C185592680 @default.
• W2000660448 hasConceptScore W2000660448C2780902042 @default.

• next