FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000661860> ?p ?o ?g. }

• W2000661860 endingPage "132" @default.
• W2000661860 startingPage "125" @default.
• W2000661860 abstract "• A novel immune-modulating protein HtdY was discovered by dynamic immunoproteomics. • Mycobacterial HtdY might contribute to the persistence of the TB infection. • Mycobacterial HtdY induced COX-2 expression through MAPK-NF-κB signaling pathway. Tuberculosis (TB) is a leading cause of global mortality due to infectious diseases. Expression of cyclooxygenase-2 (COX-2) acts as an important influencing factor favoring bacillary survival during TB infection. In this study, we investigated the Mycobacterium tuberculosis proteins recognized by sera from TB patient collected before and after anti-TB therapy by dynamic immunoproteomics and identified a novel immune-regulating protein 3-hydroxyacyl-l-thioester dehydratase Y (HtdY), which could induce COX-2 expression in mouse macrophages. Signaling perturbation data showed that the activation of p38, ERK 1/2 and JNK 1/2 MAPK as well as NF-κB played critical role in this immune response. Taken together, our findings indicated that mycobacterial HtdY might contribute to the persistence of the TB infection by inducing COX-2 expression through MAPK-NF-κB signaling pathway." @default.
• W2000661860 created "2016-06-24" @default.
• W2000661860 creator A5001591463 @default.
• W2000661860 creator A5001931100 @default.
• W2000661860 creator A5009740641 @default.
• W2000661860 creator A5010776860 @default.
• W2000661860 creator A5015762821 @default.
• W2000661860 creator A5021003122 @default.
• W2000661860 creator A5027835055 @default.
• W2000661860 creator A5040588043 @default.
• W2000661860 creator A5055508199 @default.
• W2000661860 creator A5055514145 @default.
• W2000661860 creator A5077176756 @default.
• W2000661860 date "2014-09-01" @default.
• W2000661860 modified "2023-10-18" @default.
• W2000661860 title "Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-κB pathway" @default.
• W2000661860 cites W1492745024 @default.
• W2000661860 cites W1629604081 @default.
• W2000661860 cites W169842838 @default.
• W2000661860 cites W1811883818 @default.
• W2000661860 cites W1961207913 @default.
• W2000661860 cites W1970751856 @default.
• W2000661860 cites W2007740082 @default.
• W2000661860 cites W2012013728 @default.
• W2000661860 cites W2012144531 @default.
• W2000661860 cites W2014427579 @default.
• W2000661860 cites W2016768498 @default.
• W2000661860 cites W2027455101 @default.
• W2000661860 cites W2031227424 @default.
• W2000661860 cites W2033049864 @default.
• W2000661860 cites W2034329420 @default.
• W2000661860 cites W2035136072 @default.
• W2000661860 cites W2048961513 @default.
• W2000661860 cites W2049853880 @default.
• W2000661860 cites W2056844634 @default.
• W2000661860 cites W2062409682 @default.
• W2000661860 cites W2064964564 @default.
• W2000661860 cites W2079013052 @default.
• W2000661860 cites W2081773790 @default.
• W2000661860 cites W2089060011 @default.
• W2000661860 cites W2089727089 @default.
• W2000661860 cites W2095357096 @default.
• W2000661860 cites W2100531445 @default.
• W2000661860 cites W2103028385 @default.
• W2000661860 cites W2109030711 @default.
• W2000661860 cites W2110807603 @default.
• W2000661860 cites W2116676783 @default.
• W2000661860 cites W2118181695 @default.
• W2000661860 cites W2129959902 @default.
• W2000661860 cites W2138694018 @default.
• W2000661860 cites W2144685626 @default.
• W2000661860 cites W2148761057 @default.
• W2000661860 cites W2158023121 @default.
• W2000661860 cites W2160375280 @default.
• W2000661860 cites W2160517489 @default.
• W2000661860 cites W2161012092 @default.
• W2000661860 cites W2164309428 @default.
• W2000661860 cites W2165020270 @default.
• W2000661860 cites W2168062702 @default.
• W2000661860 doi "https://doi.org/10.1016/j.imlet.2014.05.013" @default.
• W2000661860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24907510" @default.
• W2000661860 hasPublicationYear "2014" @default.
• W2000661860 type Work @default.
• W2000661860 sameAs 2000661860 @default.
• W2000661860 citedByCount "5" @default.
• W2000661860 countsByYear W20006618602017 @default.
• W2000661860 countsByYear W20006618602019 @default.
• W2000661860 countsByYear W20006618602021 @default.
• W2000661860 countsByYear W20006618602023 @default.
• W2000661860 crossrefType "journal-article" @default.
• W2000661860 hasAuthorship W2000661860A5001591463 @default.
• W2000661860 hasAuthorship W2000661860A5001931100 @default.
• W2000661860 hasAuthorship W2000661860A5009740641 @default.
• W2000661860 hasAuthorship W2000661860A5010776860 @default.
• W2000661860 hasAuthorship W2000661860A5015762821 @default.
• W2000661860 hasAuthorship W2000661860A5021003122 @default.
• W2000661860 hasAuthorship W2000661860A5027835055 @default.
• W2000661860 hasAuthorship W2000661860A5040588043 @default.
• W2000661860 hasAuthorship W2000661860A5055508199 @default.
• W2000661860 hasAuthorship W2000661860A5055514145 @default.
• W2000661860 hasAuthorship W2000661860A5077176756 @default.
• W2000661860 hasConcept C142724271 @default.
• W2000661860 hasConcept C203014093 @default.
• W2000661860 hasConcept C2776914184 @default.
• W2000661860 hasConcept C2777730290 @default.
• W2000661860 hasConcept C2777975735 @default.
• W2000661860 hasConcept C2781069245 @default.
• W2000661860 hasConcept C502942594 @default.
• W2000661860 hasConcept C57074206 @default.
• W2000661860 hasConcept C62478195 @default.
• W2000661860 hasConcept C71924100 @default.
• W2000661860 hasConcept C86803240 @default.
• W2000661860 hasConcept C8891405 @default.
• W2000661860 hasConcept C95444343 @default.
• W2000661860 hasConceptScore W2000661860C142724271 @default.
• W2000661860 hasConceptScore W2000661860C203014093 @default.
• W2000661860 hasConceptScore W2000661860C2776914184 @default.
• W2000661860 hasConceptScore W2000661860C2777730290 @default.

• next