FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000662071> ?p ?o ?g. }

• W2000662071 endingPage "2228" @default.
• W2000662071 startingPage "2222" @default.
• W2000662071 abstract "Background: Recent observational studies suggest that bleeding from stress ulceration is extremely uncommon in intensive care unit patients. Furthermore, the risk of bleeding may not be altered by the use of acid suppressive therapy. Early enteral tube feeding (initiated within 48 hrs of intensive care unit admission) may account for this observation. Stress ulcer prophylaxis may, however, increase the risk of hospital-acquired pneumonia and Clostridiadifficile infection. Objective: A systematic review of the literature to determine the benefit and risks of stress ulcer prophylaxis and the moderating effect of enteral nutrition. Data Sources: MEDLINE, Embase, Cochrane Register of Controlled Trials, and citation review of relevant primary and review articles. Study Selection: Randomized, controlled studies that evaluated the association between stress ulcer prophylaxis and gastrointestinal bleeding. We included only those studies that compared a histamine-2 receptor blocker with a placebo. Data Extraction: Data were abstracted on study design, study size, study setting, patient population, the histamine-2 receptor blocker and dosage used, the incidence of clinically significant gastrointestinal bleeding, hospital-acquired pneumonia, mortality, and the use of enteral nutrition. Data Synthesis: Seventeen studies (which enrolled 1836 patients) met the inclusion criteria. Patients received adequate enteral nutrition in three of the studies. Overall, stress ulcer prophylaxis with a histamine-2 receptor blocker reduced the risk of gastrointestinal bleeding (odds ratio 0.47; 95% confidence interval, 0.29-0.76; p < .002; I2 = 44%); however, the treatment effect was noted only in the subgroup of patients who did not receive enteral nutrition. In those patients who were fed enterally, stress ulcer prophylaxis did not alter the risk of gastrointestinal bleeding (odds ratio 1.26; 95% confidence interval, 0.43-3.7). Overall histamine-2 receptor blockers did not increase the risk of hospital-acquired pneumonia (odds ratio 1.53; 95% confidence interval, 0.89-2.61; p = .12; I2 = 41%); however, this complication was increased in the subgroup of patients who were fed enterally (odds ratio 2.81; 95% confidence interval, 1.20-6.56; p = .02; I2 = 0%). Overall, stress ulcer prophylaxis had no effect on hospital mortality (odds ratio 1.03; 95% confidence interval, 0.78-1.37; p = .82). The hospital mortality was, however, higher in those studies (n = 2) in which patients were fed enterally and received a histamine-2 receptor blocker (odds ratio 1.89; 95% confidence interval, 1.04-3.44; p = .04, I2 = 0%). Sensitivity analysis and meta-regression demonstrated no relationship between the treatment effect (risk of gastrointestinal bleeding) and the classification used to define gastrointestinal bleeding, the Jadad quality score nor the year the study was reported. Conclusions: The results of this meta-analysis suggest that, in those patients receiving enteral nutrition, stress ulcer prophylaxis may not be required and, indeed, such therapy may increase the risk of pneumonia and death. However, because no clinical study has prospectively tested the influence of enteral nutrition on the risk of stress ulcer prophylaxis, our findings should be considered exploratory and interpreted with some caution." @default.
• W2000662071 created "2016-06-24" @default.
• W2000662071 creator A5020239629 @default.
• W2000662071 creator A5048442496 @default.
• W2000662071 creator A5062367983 @default.
• W2000662071 creator A5073452793 @default.
• W2000662071 date "2010-11-01" @default.
• W2000662071 modified "2023-10-03" @default.
• W2000662071 title "Stress ulcer prophylaxis in the new millennium: A systematic review and meta-analysis" @default.
• W2000662071 cites W1547996934 @default.
• W2000662071 cites W1967449950 @default.
• W2000662071 cites W1975448780 @default.
• W2000662071 cites W1978463699 @default.
• W2000662071 cites W1986215651 @default.
• W2000662071 cites W1989739773 @default.
• W2000662071 cites W1998590980 @default.
• W2000662071 cites W2000442546 @default.
• W2000662071 cites W2005669815 @default.
• W2000662071 cites W2007976642 @default.
• W2000662071 cites W2017665239 @default.
• W2000662071 cites W2019897899 @default.
• W2000662071 cites W2020375001 @default.
• W2000662071 cites W2029577585 @default.
• W2000662071 cites W2030440711 @default.
• W2000662071 cites W2031895054 @default.
• W2000662071 cites W2033404332 @default.
• W2000662071 cites W2035146812 @default.
• W2000662071 cites W2038043605 @default.
• W2000662071 cites W2043794877 @default.
• W2000662071 cites W2050654120 @default.
• W2000662071 cites W2055620951 @default.
• W2000662071 cites W2058000687 @default.
• W2000662071 cites W2058435821 @default.
• W2000662071 cites W2058514642 @default.
• W2000662071 cites W2065712370 @default.
• W2000662071 cites W2066656570 @default.
• W2000662071 cites W2078638629 @default.
• W2000662071 cites W2084254640 @default.
• W2000662071 cites W2085100811 @default.
• W2000662071 cites W2085994826 @default.
• W2000662071 cites W2089973354 @default.
• W2000662071 cites W2091105678 @default.
• W2000662071 cites W2109036048 @default.
• W2000662071 cites W2109134621 @default.
• W2000662071 cites W2118009919 @default.
• W2000662071 cites W2125435699 @default.
• W2000662071 cites W2126110907 @default.
• W2000662071 cites W2126930838 @default.
• W2000662071 cites W2139301698 @default.
• W2000662071 cites W2144622777 @default.
• W2000662071 cites W2144724880 @default.
• W2000662071 cites W2149675013 @default.
• W2000662071 cites W2152957028 @default.
• W2000662071 cites W2167351485 @default.
• W2000662071 cites W2172013779 @default.
• W2000662071 cites W2316130350 @default.
• W2000662071 cites W2321262375 @default.
• W2000662071 cites W2803743745 @default.
• W2000662071 cites W3017100980 @default.
• W2000662071 doi "https://doi.org/10.1097/ccm.0b013e3181f17adf" @default.
• W2000662071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20711074" @default.
• W2000662071 hasPublicationYear "2010" @default.
• W2000662071 type Work @default.
• W2000662071 sameAs 2000662071 @default.
• W2000662071 citedByCount "201" @default.
• W2000662071 countsByYear W20006620712012 @default.
• W2000662071 countsByYear W20006620712013 @default.
• W2000662071 countsByYear W20006620712014 @default.
• W2000662071 countsByYear W20006620712015 @default.
• W2000662071 countsByYear W20006620712016 @default.
• W2000662071 countsByYear W20006620712017 @default.
• W2000662071 countsByYear W20006620712018 @default.
• W2000662071 countsByYear W20006620712019 @default.
• W2000662071 countsByYear W20006620712020 @default.
• W2000662071 countsByYear W20006620712021 @default.
• W2000662071 countsByYear W20006620712022 @default.
• W2000662071 countsByYear W20006620712023 @default.
• W2000662071 crossrefType "journal-article" @default.
• W2000662071 hasAuthorship W2000662071A5020239629 @default.
• W2000662071 hasAuthorship W2000662071A5048442496 @default.
• W2000662071 hasAuthorship W2000662071A5062367983 @default.
• W2000662071 hasAuthorship W2000662071A5073452793 @default.
• W2000662071 hasConcept C126322002 @default.
• W2000662071 hasConcept C142724271 @default.
• W2000662071 hasConcept C156957248 @default.
• W2000662071 hasConcept C177713679 @default.
• W2000662071 hasConcept C204787440 @default.
• W2000662071 hasConcept C27081682 @default.
• W2000662071 hasConcept C2776246392 @default.
• W2000662071 hasConcept C2776376669 @default.
• W2000662071 hasConcept C2776672619 @default.
• W2000662071 hasConcept C2777080012 @default.
• W2000662071 hasConcept C2778080469 @default.
• W2000662071 hasConcept C2908647359 @default.
• W2000662071 hasConcept C2987404301 @default.
• W2000662071 hasConcept C44249647 @default.
• W2000662071 hasConcept C44315111 @default.
• W2000662071 hasConcept C71924100 @default.

• next