Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000662832> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2000662832 endingPage "127a" @default.
- W2000662832 startingPage "127a" @default.
- W2000662832 abstract "CACNA1F encodes the alpha1 subunit of retina-specific Cav1.4 voltage-gated L type calcium channels. Mutations in this gene cause congenital stationary night blindness type 2A (CSNB2), Aland Island eye disease (AIED) and cone-rod dystrophy type 3 (CORDX3). The clinical phenotypes of these eye diseases vary substantially regarding the ratio of rod to cone functional impairment. The reasons for this variability are not known. To gain more insights into the pathophysiology caused by loss of Cav1.4 function we analyzed the visual phenotype of Cav1.4-deficient mice. To this end, we combined immunohistochemistry, electroretinography (ERG) and vision-dependent behavioral testing. Immunohistochemical analysis using synaptic and postsynaptic markers revealed severe synaptic defects in Cav1.4-deficient mice. Heterozygous Cav1.4 mice showed mosaic synaptic defects most probably caused by random X-chromosomal inactivation of the healthy allele. Electroretinography revealed a loss of scotopic and photopic photoreceptor function. This loss of retinal network function resulted in impaired perfomance of Cav1.4 knockout mice in a water maze-based behavioral test of rod and cone function. In conclusion, loss of Cav1.4 channels strongly impairs rod and cone retinal function and vision in mice." @default.
- W2000662832 created "2016-06-24" @default.
- W2000662832 creator A5012761831 @default.
- W2000662832 creator A5012791378 @default.
- W2000662832 creator A5021299759 @default.
- W2000662832 creator A5023140748 @default.
- W2000662832 creator A5034889496 @default.
- W2000662832 creator A5075508364 @default.
- W2000662832 creator A5085840167 @default.
- W2000662832 creator A5089190614 @default.
- W2000662832 creator A5090188941 @default.
- W2000662832 date "2012-01-01" @default.
- W2000662832 modified "2023-09-28" @default.
- W2000662832 title "Visual Function in CaV1.4-Deficient Mice" @default.
- W2000662832 doi "https://doi.org/10.1016/j.bpj.2011.11.706" @default.
- W2000662832 hasPublicationYear "2012" @default.
- W2000662832 type Work @default.
- W2000662832 sameAs 2000662832 @default.
- W2000662832 citedByCount "0" @default.
- W2000662832 crossrefType "journal-article" @default.
- W2000662832 hasAuthorship W2000662832A5012761831 @default.
- W2000662832 hasAuthorship W2000662832A5012791378 @default.
- W2000662832 hasAuthorship W2000662832A5021299759 @default.
- W2000662832 hasAuthorship W2000662832A5023140748 @default.
- W2000662832 hasAuthorship W2000662832A5034889496 @default.
- W2000662832 hasAuthorship W2000662832A5075508364 @default.
- W2000662832 hasAuthorship W2000662832A5085840167 @default.
- W2000662832 hasAuthorship W2000662832A5089190614 @default.
- W2000662832 hasAuthorship W2000662832A5090188941 @default.
- W2000662832 hasBestOaLocation W20006628321 @default.
- W2000662832 hasConcept C103796816 @default.
- W2000662832 hasConcept C104317684 @default.
- W2000662832 hasConcept C105702510 @default.
- W2000662832 hasConcept C105951970 @default.
- W2000662832 hasConcept C118487528 @default.
- W2000662832 hasConcept C127716648 @default.
- W2000662832 hasConcept C169760540 @default.
- W2000662832 hasConcept C2777017193 @default.
- W2000662832 hasConcept C2777093970 @default.
- W2000662832 hasConcept C2779113765 @default.
- W2000662832 hasConcept C2780827179 @default.
- W2000662832 hasConcept C2781040256 @default.
- W2000662832 hasConcept C2910227669 @default.
- W2000662832 hasConcept C54355233 @default.
- W2000662832 hasConcept C54497739 @default.
- W2000662832 hasConcept C71924100 @default.
- W2000662832 hasConcept C7243750 @default.
- W2000662832 hasConcept C86803240 @default.
- W2000662832 hasConceptScore W2000662832C103796816 @default.
- W2000662832 hasConceptScore W2000662832C104317684 @default.
- W2000662832 hasConceptScore W2000662832C105702510 @default.
- W2000662832 hasConceptScore W2000662832C105951970 @default.
- W2000662832 hasConceptScore W2000662832C118487528 @default.
- W2000662832 hasConceptScore W2000662832C127716648 @default.
- W2000662832 hasConceptScore W2000662832C169760540 @default.
- W2000662832 hasConceptScore W2000662832C2777017193 @default.
- W2000662832 hasConceptScore W2000662832C2777093970 @default.
- W2000662832 hasConceptScore W2000662832C2779113765 @default.
- W2000662832 hasConceptScore W2000662832C2780827179 @default.
- W2000662832 hasConceptScore W2000662832C2781040256 @default.
- W2000662832 hasConceptScore W2000662832C2910227669 @default.
- W2000662832 hasConceptScore W2000662832C54355233 @default.
- W2000662832 hasConceptScore W2000662832C54497739 @default.
- W2000662832 hasConceptScore W2000662832C71924100 @default.
- W2000662832 hasConceptScore W2000662832C7243750 @default.
- W2000662832 hasConceptScore W2000662832C86803240 @default.
- W2000662832 hasIssue "3" @default.
- W2000662832 hasLocation W20006628321 @default.
- W2000662832 hasOpenAccess W2000662832 @default.
- W2000662832 hasPrimaryLocation W20006628321 @default.
- W2000662832 hasRelatedWork W1600309569 @default.
- W2000662832 hasRelatedWork W1973751261 @default.
- W2000662832 hasRelatedWork W2003558219 @default.
- W2000662832 hasRelatedWork W2006597317 @default.
- W2000662832 hasRelatedWork W2024748322 @default.
- W2000662832 hasRelatedWork W2048547328 @default.
- W2000662832 hasRelatedWork W2050791189 @default.
- W2000662832 hasRelatedWork W2096701994 @default.
- W2000662832 hasRelatedWork W2102247913 @default.
- W2000662832 hasRelatedWork W2111857934 @default.
- W2000662832 hasRelatedWork W2115715721 @default.
- W2000662832 hasRelatedWork W2136128026 @default.
- W2000662832 hasRelatedWork W2143031572 @default.
- W2000662832 hasRelatedWork W2148746649 @default.
- W2000662832 hasRelatedWork W2299646541 @default.
- W2000662832 hasRelatedWork W2329453610 @default.
- W2000662832 hasRelatedWork W2518641200 @default.
- W2000662832 hasRelatedWork W2901399072 @default.
- W2000662832 hasRelatedWork W2908405963 @default.
- W2000662832 hasRelatedWork W2949686211 @default.
- W2000662832 hasVolume "102" @default.
- W2000662832 isParatext "false" @default.
- W2000662832 isRetracted "false" @default.
- W2000662832 magId "2000662832" @default.
- W2000662832 workType "article" @default.