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- W2000662946 abstract "Abstract Rats received single unilateral stereotaxic injections of 2 μg of kainic acid into the left caudate nucleus 10 days before sacrifice. On the lesioned side, a significant reduction of endogenous taurine levels and high affinity uptake of 3H-taurine into crude synaptosomal (P2) fractions to about 75% of control values was found. In agreement with previous reports on the neurotoxic action of kainic acid, a marked reduction of endogenous GABA levels and 14C-GABA uptake into P2-fractions was observed, while 3H-dopamine uptake was not significantly changed. In superfusion experiments with prelabeled P2-fractions prepared from lesioned striata, K+(56 mM)-induced release of 3H-taurine and 14C-GABA, but not of 3H-dopamine, was reduced. The results are compatible with the hypothesis that taurine in the striatum of the rat is partially localized in interneurones." @default.
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- W2000662946 date "1979-04-01" @default.
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- W2000662946 title "Reduction of endogenous level, uptake and release of taurine after intrastriatal kainic acid injection" @default.
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- W2000662946 doi "https://doi.org/10.1016/0028-3908(79)90148-5" @default.
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