FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000663401> ?p ?o ?g. }

• W2000663401 endingPage "259" @default.
• W2000663401 startingPage "253" @default.
• W2000663401 abstract "The immune system must be under tight control to avoid undesired responses. The enzyme indoleamine 2,3-dioxygenase (IDO) can exert necessary regulating effects by catabolizing tryptophan, leading to the suppression of immune responses in different settings, such as pregnancy and tumor growth. IDO's immuno-suppressive actions are mediated by tryptophan starvation and the accumulation of toxic tryptophan metabolites, resulting in T cell anergy, inhibition of clonal expansion or apoptosis. IDO activity in human macrophages and dendritic cells has been observed after interaction with T lymphocytes, and is triggered by interferon-gamma (IFN-γ) as well as CD40-ligand (CD40L). However, it is unclear whether IDO activity is present in B lymphocytes, which have been identified as having suppressive properties involved in anti-tumor immunity inhibition. In this study, we investigated whether IDO expression is induced in human B cells after exposure to T lymphocyte stimuli and TLR ligands. We report IDO1 and IDO2 mRNA up-regulation by exogenous stimulation with CD40L and IFN-γ. IDO is also upregulated by imiquimod, a TLR 7/8 agonist. In addition, IDO protein is detected after treatment with these exogenous factors or with supernatant from activated CD4+ T cells. We, however, report weak or absent enzymatic activity from these IDO-expressing cells, as assessed by tryptophan consumption. We conclude that IDO may not be a counter-regulatory mechanism utilized by B lymphocytes to down-regulate immune responses, although its expression is inducible." @default.
• W2000663401 created "2016-06-24" @default.
• W2000663401 creator A5019572378 @default.
• W2000663401 creator A5052871815 @default.
• W2000663401 creator A5055877308 @default.
• W2000663401 creator A5079119316 @default.
• W2000663401 creator A5090301811 @default.
• W2000663401 date "2011-10-01" @default.
• W2000663401 modified "2023-10-07" @default.
• W2000663401 title "IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive" @default.
• W2000663401 cites W1834981029 @default.
• W2000663401 cites W1947375451 @default.
• W2000663401 cites W1967404929 @default.
• W2000663401 cites W1972775674 @default.
• W2000663401 cites W1973251492 @default.
• W2000663401 cites W1974401900 @default.
• W2000663401 cites W1983093044 @default.
• W2000663401 cites W1984131923 @default.
• W2000663401 cites W1986141266 @default.
• W2000663401 cites W1991243877 @default.
• W2000663401 cites W1998932146 @default.
• W2000663401 cites W2015260577 @default.
• W2000663401 cites W2021366252 @default.
• W2000663401 cites W2022430924 @default.
• W2000663401 cites W2025156511 @default.
• W2000663401 cites W2046424438 @default.
• W2000663401 cites W2047027176 @default.
• W2000663401 cites W2053217888 @default.
• W2000663401 cites W2071514741 @default.
• W2000663401 cites W2072078248 @default.
• W2000663401 cites W2085802461 @default.
• W2000663401 cites W2105117087 @default.
• W2000663401 cites W2108244474 @default.
• W2000663401 cites W2114761018 @default.
• W2000663401 cites W2115527312 @default.
• W2000663401 cites W2117446006 @default.
• W2000663401 cites W2122012981 @default.
• W2000663401 cites W2122285073 @default.
• W2000663401 cites W2138319166 @default.
• W2000663401 cites W2140657592 @default.
• W2000663401 cites W2146914242 @default.
• W2000663401 cites W2152857351 @default.
• W2000663401 cites W2154594040 @default.
• W2000663401 cites W2167897482 @default.
• W2000663401 cites W2397320519 @default.
• W2000663401 cites W4253434423 @default.
• W2000663401 doi "https://doi.org/10.1016/j.molimm.2011.08.017" @default.
• W2000663401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21937116" @default.
• W2000663401 hasPublicationYear "2011" @default.
• W2000663401 type Work @default.
• W2000663401 sameAs 2000663401 @default.
• W2000663401 citedByCount "29" @default.
• W2000663401 countsByYear W20006634012013 @default.
• W2000663401 countsByYear W20006634012014 @default.
• W2000663401 countsByYear W20006634012015 @default.
• W2000663401 countsByYear W20006634012016 @default.
• W2000663401 countsByYear W20006634012017 @default.
• W2000663401 countsByYear W20006634012018 @default.
• W2000663401 countsByYear W20006634012019 @default.
• W2000663401 countsByYear W20006634012020 @default.
• W2000663401 countsByYear W20006634012021 @default.
• W2000663401 countsByYear W20006634012022 @default.
• W2000663401 countsByYear W20006634012023 @default.
• W2000663401 crossrefType "journal-article" @default.
• W2000663401 hasAuthorship W2000663401A5019572378 @default.
• W2000663401 hasAuthorship W2000663401A5052871815 @default.
• W2000663401 hasAuthorship W2000663401A5055877308 @default.
• W2000663401 hasAuthorship W2000663401A5079119316 @default.
• W2000663401 hasAuthorship W2000663401A5090301811 @default.
• W2000663401 hasConcept C154317977 @default.
• W2000663401 hasConcept C202751555 @default.
• W2000663401 hasConcept C203014093 @default.
• W2000663401 hasConcept C2776706248 @default.
• W2000663401 hasConcept C2777702733 @default.
• W2000663401 hasConcept C2777761686 @default.
• W2000663401 hasConcept C39347974 @default.
• W2000663401 hasConcept C515207424 @default.
• W2000663401 hasConcept C55493867 @default.
• W2000663401 hasConcept C83478079 @default.
• W2000663401 hasConcept C86803240 @default.
• W2000663401 hasConcept C8891405 @default.
• W2000663401 hasConcept C95444343 @default.
• W2000663401 hasConceptScore W2000663401C154317977 @default.
• W2000663401 hasConceptScore W2000663401C202751555 @default.
• W2000663401 hasConceptScore W2000663401C203014093 @default.
• W2000663401 hasConceptScore W2000663401C2776706248 @default.
• W2000663401 hasConceptScore W2000663401C2777702733 @default.
• W2000663401 hasConceptScore W2000663401C2777761686 @default.
• W2000663401 hasConceptScore W2000663401C39347974 @default.
• W2000663401 hasConceptScore W2000663401C515207424 @default.
• W2000663401 hasConceptScore W2000663401C55493867 @default.
• W2000663401 hasConceptScore W2000663401C83478079 @default.
• W2000663401 hasConceptScore W2000663401C86803240 @default.
• W2000663401 hasConceptScore W2000663401C8891405 @default.
• W2000663401 hasConceptScore W2000663401C95444343 @default.
• W2000663401 hasFunder F4320334506 @default.
• W2000663401 hasFunder F4320334593 @default.
• W2000663401 hasIssue "1-2" @default.

• next