Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000663742> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2000663742 endingPage "2541" @default.
- W2000663742 startingPage "2535" @default.
- W2000663742 abstract "Recognition of the mRNA cap structure by the translation initiation factor eIF4E is central to pro-tein synthesis in general and eIF4E activity is especially important for the production of many of the proteins that give rise to the hallmarks of cancer. Because transformed cells have a height-ened requirement for the expression of prosurvival factors, targeting translation appears to be an attractive anticancer strategy and proof-of-concept studies in which oncogenic eIF4E function is suppressed in various different ways show that tumour cells are selectively sensitive to inhibition of protein synthesis at the level of eIF4E. The emerging understanding of the functions, regula-tion, and structural biology of eIF4E now makes possible the pharmacological targeting of this key translation initiation factor." @default.
- W2000663742 created "2016-06-24" @default.
- W2000663742 creator A5041852883 @default.
- W2000663742 date "2009-08-15" @default.
- W2000663742 modified "2023-10-01" @default.
- W2000663742 title "Cap in hand: Targeting eIF4E" @default.
- W2000663742 doi "https://doi.org/10.4161/cc.8.16.9301" @default.
- W2000663742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19597330" @default.
- W2000663742 hasPublicationYear "2009" @default.
- W2000663742 type Work @default.
- W2000663742 sameAs 2000663742 @default.
- W2000663742 citedByCount "55" @default.
- W2000663742 countsByYear W20006637422012 @default.
- W2000663742 countsByYear W20006637422013 @default.
- W2000663742 countsByYear W20006637422014 @default.
- W2000663742 countsByYear W20006637422015 @default.
- W2000663742 countsByYear W20006637422016 @default.
- W2000663742 countsByYear W20006637422017 @default.
- W2000663742 countsByYear W20006637422018 @default.
- W2000663742 countsByYear W20006637422019 @default.
- W2000663742 countsByYear W20006637422020 @default.
- W2000663742 countsByYear W20006637422021 @default.
- W2000663742 countsByYear W20006637422022 @default.
- W2000663742 countsByYear W20006637422023 @default.
- W2000663742 crossrefType "journal-article" @default.
- W2000663742 hasAuthorship W2000663742A5041852883 @default.
- W2000663742 hasBestOaLocation W20006637421 @default.
- W2000663742 hasConcept C104317684 @default.
- W2000663742 hasConcept C105580179 @default.
- W2000663742 hasConcept C14036430 @default.
- W2000663742 hasConcept C149364088 @default.
- W2000663742 hasConcept C153911025 @default.
- W2000663742 hasConcept C161295673 @default.
- W2000663742 hasConcept C3675279 @default.
- W2000663742 hasConcept C4718897 @default.
- W2000663742 hasConcept C502942594 @default.
- W2000663742 hasConcept C54355233 @default.
- W2000663742 hasConcept C86803240 @default.
- W2000663742 hasConcept C95444343 @default.
- W2000663742 hasConceptScore W2000663742C104317684 @default.
- W2000663742 hasConceptScore W2000663742C105580179 @default.
- W2000663742 hasConceptScore W2000663742C14036430 @default.
- W2000663742 hasConceptScore W2000663742C149364088 @default.
- W2000663742 hasConceptScore W2000663742C153911025 @default.
- W2000663742 hasConceptScore W2000663742C161295673 @default.
- W2000663742 hasConceptScore W2000663742C3675279 @default.
- W2000663742 hasConceptScore W2000663742C4718897 @default.
- W2000663742 hasConceptScore W2000663742C502942594 @default.
- W2000663742 hasConceptScore W2000663742C54355233 @default.
- W2000663742 hasConceptScore W2000663742C86803240 @default.
- W2000663742 hasConceptScore W2000663742C95444343 @default.
- W2000663742 hasIssue "16" @default.
- W2000663742 hasLocation W20006637421 @default.
- W2000663742 hasLocation W20006637422 @default.
- W2000663742 hasOpenAccess W2000663742 @default.
- W2000663742 hasPrimaryLocation W20006637421 @default.
- W2000663742 hasRelatedWork W1993089918 @default.
- W2000663742 hasRelatedWork W2000663742 @default.
- W2000663742 hasRelatedWork W2025743385 @default.
- W2000663742 hasRelatedWork W2056046101 @default.
- W2000663742 hasRelatedWork W2140135037 @default.
- W2000663742 hasRelatedWork W2161624752 @default.
- W2000663742 hasRelatedWork W2312098803 @default.
- W2000663742 hasRelatedWork W3039603086 @default.
- W2000663742 hasRelatedWork W3169819870 @default.
- W2000663742 hasRelatedWork W4244281176 @default.
- W2000663742 hasVolume "8" @default.
- W2000663742 isParatext "false" @default.
- W2000663742 isRetracted "false" @default.
- W2000663742 magId "2000663742" @default.
- W2000663742 workType "article" @default.