FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000664074> ?p ?o ?g. }

• W2000664074 endingPage "1098" @default.
• W2000664074 startingPage "1091" @default.
• W2000664074 abstract "HIV-1 gene expression in kidney epithelial cells is thought to be responsible for the pathogenesis of HIV-1-associated nephropathy (HIVAN). Signal transducer and activator of transcription (STAT) 3 signaling is activated in podocytes of patients with HIVAN and drives the dedifferentiation and proliferation of podocytes in culture. We confirm here that deletion of podocyte STAT3 is sufficient to mitigate the glomerular as well as tubulointerstitial findings of HIVAN.To demonstrate the functional role of podocyte STAT3 in the pathogenesis of HIVAN we compared the development of HIVAN in Tg26 HIV-transgenic mice with and without deletion of STAT3 in the podocyte.Tg26 mice with podocyte-specific STAT3 deletion developed significantly less weight loss, albuminuria, and renal function impairment compared to Tg26 mice without STAT3 deletion. Tg26 mice with podocyte STAT3 deletion also had significantly less glomerular collapse, sclerosis, epithelial cell hyperplasia, podocyte dedifferentiation, and proinflammatory STAT3 target gene expression; and tubulointerstitial changes of HIVAN, including tubular atrophy, degeneration, apoptosis, and lymphocyte infiltration, were also significantly reduced compared to Tg26 mice without STAT3 deletion.Development of glomerular as well as tubulointerstitial injuries in the Tg26 HIVAN model is dependent on podocyte STAT3 expression. Inhibition of STAT3 could be a potential adjunctive therapy for the treatment of HIVAN." @default.
• W2000664074 created "2016-06-24" @default.
• W2000664074 creator A5008659038 @default.
• W2000664074 creator A5014236405 @default.
• W2000664074 creator A5021913849 @default.
• W2000664074 creator A5025947755 @default.
• W2000664074 creator A5033563716 @default.
• W2000664074 creator A5044404332 @default.
• W2000664074 creator A5055025477 @default.
• W2000664074 creator A5069630937 @default.
• W2000664074 date "2013-04-24" @default.
• W2000664074 modified "2023-09-26" @default.
• W2000664074 title "Deletion of podocyte STAT3 mitigates the entire spectrum of HIV-1-associated nephropathy" @default.
• W2000664074 cites W1963937649 @default.
• W2000664074 cites W1981542507 @default.
• W2000664074 cites W1990488096 @default.
• W2000664074 cites W1991447679 @default.
• W2000664074 cites W1991719590 @default.
• W2000664074 cites W1997626748 @default.
• W2000664074 cites W1999218213 @default.
• W2000664074 cites W2006543103 @default.
• W2000664074 cites W2007061834 @default.
• W2000664074 cites W2007501395 @default.
• W2000664074 cites W2011323181 @default.
• W2000664074 cites W2018509996 @default.
• W2000664074 cites W2020050993 @default.
• W2000664074 cites W2044183928 @default.
• W2000664074 cites W2051719011 @default.
• W2000664074 cites W2068837792 @default.
• W2000664074 cites W2069045375 @default.
• W2000664074 cites W2082387503 @default.
• W2000664074 cites W2085796905 @default.
• W2000664074 cites W2122093638 @default.
• W2000664074 cites W2123139460 @default.
• W2000664074 cites W2127822034 @default.
• W2000664074 cites W2135241380 @default.
• W2000664074 cites W2144535466 @default.
• W2000664074 cites W2152144608 @default.
• W2000664074 cites W2155357669 @default.
• W2000664074 cites W2155821873 @default.
• W2000664074 cites W2159686293 @default.
• W2000664074 cites W2342753235 @default.
• W2000664074 cites W4249614921 @default.
• W2000664074 doi "https://doi.org/10.1097/qad.0b013e32835f1ea1" @default.
• W2000664074 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3918880" @default.
• W2000664074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23343908" @default.
• W2000664074 hasPublicationYear "2013" @default.
• W2000664074 type Work @default.
• W2000664074 sameAs 2000664074 @default.
• W2000664074 citedByCount "35" @default.
• W2000664074 countsByYear W20006640742013 @default.
• W2000664074 countsByYear W20006640742014 @default.
• W2000664074 countsByYear W20006640742015 @default.
• W2000664074 countsByYear W20006640742016 @default.
• W2000664074 countsByYear W20006640742017 @default.
• W2000664074 countsByYear W20006640742018 @default.
• W2000664074 countsByYear W20006640742019 @default.
• W2000664074 countsByYear W20006640742020 @default.
• W2000664074 countsByYear W20006640742021 @default.
• W2000664074 countsByYear W20006640742022 @default.
• W2000664074 countsByYear W20006640742023 @default.
• W2000664074 crossrefType "journal-article" @default.
• W2000664074 hasAuthorship W2000664074A5008659038 @default.
• W2000664074 hasAuthorship W2000664074A5014236405 @default.
• W2000664074 hasAuthorship W2000664074A5021913849 @default.
• W2000664074 hasAuthorship W2000664074A5025947755 @default.
• W2000664074 hasAuthorship W2000664074A5033563716 @default.
• W2000664074 hasAuthorship W2000664074A5044404332 @default.
• W2000664074 hasAuthorship W2000664074A5055025477 @default.
• W2000664074 hasAuthorship W2000664074A5069630937 @default.
• W2000664074 hasBestOaLocation W20006640741 @default.
• W2000664074 hasConcept C134018914 @default.
• W2000664074 hasConcept C171958077 @default.
• W2000664074 hasConcept C203014093 @default.
• W2000664074 hasConcept C2776174234 @default.
• W2000664074 hasConcept C2777146197 @default.
• W2000664074 hasConcept C2777390665 @default.
• W2000664074 hasConcept C2778923194 @default.
• W2000664074 hasConcept C2779561371 @default.
• W2000664074 hasConcept C2779922275 @default.
• W2000664074 hasConcept C2780091579 @default.
• W2000664074 hasConcept C2780942790 @default.
• W2000664074 hasConcept C2781184683 @default.
• W2000664074 hasConcept C502942594 @default.
• W2000664074 hasConcept C555293320 @default.
• W2000664074 hasConcept C62478195 @default.
• W2000664074 hasConcept C86803240 @default.
• W2000664074 hasConcept C95444343 @default.
• W2000664074 hasConceptScore W2000664074C134018914 @default.
• W2000664074 hasConceptScore W2000664074C171958077 @default.
• W2000664074 hasConceptScore W2000664074C203014093 @default.
• W2000664074 hasConceptScore W2000664074C2776174234 @default.
• W2000664074 hasConceptScore W2000664074C2777146197 @default.
• W2000664074 hasConceptScore W2000664074C2777390665 @default.
• W2000664074 hasConceptScore W2000664074C2778923194 @default.
• W2000664074 hasConceptScore W2000664074C2779561371 @default.
• W2000664074 hasConceptScore W2000664074C2779922275 @default.
• W2000664074 hasConceptScore W2000664074C2780091579 @default.

• next