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• W2000665002 abstract "This study analyzed the relationship between methane production and colonic transit time in children with chronic constipation.Forty children, from 3 to 13 years of age, suffering from chronic constipation were included. Methane production was defined when the breath methane concentration was greater than 3 ppm. The total and segmental colonic transit times were measured with radio-opaque markers.Soiling was present in 34 (85.0%) of 40 patients with constipation. Methane production was present in 25 of 34 (73.5%) patients with constipation and soiling and only in 1 (16.7%) of 6 with constipation but without soiling (P = 0.014). The medians of total colonic transit time were 80.5 and 61.0 hours, respectively (P = 0.04), in methane and nonmethane producers. Segmental colonic transit times were 17.5 and 10.5 hours, respectively (P = 0.580), in right colon, 29.5 and 10.5 hours (P = 0.001), respectively, in left colon, and 31.5 and 27.0 hours (P = 0.202), respectively, in the rectosigmoid. By the sixth week of treatment, the reduction in the total colonic transit time was greater in patients who had become nonmethane producers.The presence of breath methane in children with chronic constipation may suggest the possibility of prolonged colonic transit time." @default.
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• W2000665002 date "2005-07-01" @default.
• W2000665002 modified "2023-09-30" @default.
• W2000665002 title "Breath Methane Associated With Slow Colonic Transit Time in Children With Chronic Constipation" @default.
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• W2000665002 doi "https://doi.org/10.1097/01.mcg.0000165665.94777.bd" @default.
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