FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000666641> ?p ?o ?g. }

• W2000666641 endingPage "40" @default.
• W2000666641 startingPage "23" @default.
• W2000666641 abstract "The regulation of cardiac Cl − current ( I C1 ) by tyrosine and serine/threonine phosphorylation was examined in guinea‐pig and rat ventricular myocytes. The protein tyrosine kinase (PTK) inhibitor genistein (GST) and phosphotyrosine phosphatase (PTP) inhibitor sodium orthovanadate (VO 4 ) were used to modify tyrosine phosphorylation, whereas forskolin (FSK), cAMP, and other agents were used to modify cytoplasmic cAMP concentration and protein kinase A (PKA) phosphorylation. Low concentrations (0.1 μ m ) of FSK did not activate the PKA‐regulated cystic fibrosis transmembrane regulator (CFTR) I Cl in guinea‐pig ventricular myocytes, but strongly potentiated activation of an I Cl by 20–100 μ m GST. The potentiation did not occur when GST was replaced by PTK‐inactive daidzein, and it was strongly inhibited by 1 m m VO 4 . Potentiation by 0.1 μ m FSK was linked to a small stimulation of the adenylate cyclase–cAMP–PKA pathway. The potentiation was not mimicked by inactive 1,9‐dideoxyforskolin, and was inhibited by muscarinic stimulation (ACh) and by a PKA inhibitor. Internal application of a cAMP solution that alone was too weak to activate CFTR I Cl strongly potentiated the activation of I Cl by 50 μ m GST and occluded potentiation by 0.1 μ m FSK. The foregoing suggests that potentiated I Cl flows through cAMP‐dependent CFTR channels. In agreement with this interpretation, GST did not increase I Cl when CFTR was maximally activated by a high concentration (5 μ m ) of FSK and okadaic acid, and neither GST nor GST plus FSK activated an I Cl in CFTR‐deficient rat myocytes. The lack of effect in rat myocytes was not due to the absence of functional, channel‐relevant PKA and PTK–PTP systems, because (as in guinea‐pig myocytes) L‐type Ca 2+ current ( I Ca,L ) was stimulated by FSK and inhibited in a VO 4 ‐reversible manner by GST. The synergistic activation of CFTR by low concentrations of FSK and GST cannot be explained by either a GST‐induced elevation of cAMP concentration or inhibition of serine/threonine phosphatase. Rather, it appears to be due to tyrosine dephosphorylation that facilitates PKA‐mediated phosphorylation of the channels." @default.
• W2000666641 created "2016-06-24" @default.
• W2000666641 creator A5046684721 @default.
• W2000666641 creator A5053504906 @default.
• W2000666641 date "1997-11-01" @default.
• W2000666641 modified "2023-10-15" @default.
• W2000666641 title "Synergistic activation of guinea-pig cardiac cystic fibrosis transmembrane conductance regulator by the tyrosine kinase inhibitor genistein and cAMP" @default.
• W2000666641 cites W1036181247 @default.
• W2000666641 cites W1520021552 @default.
• W2000666641 cites W1565234800 @default.
• W2000666641 cites W1565303318 @default.
• W2000666641 cites W1599059671 @default.
• W2000666641 cites W1899877571 @default.
• W2000666641 cites W1978949832 @default.
• W2000666641 cites W1998341622 @default.
• W2000666641 cites W2016659590 @default.
• W2000666641 cites W2019938874 @default.
• W2000666641 cites W2026183883 @default.
• W2000666641 cites W2028135587 @default.
• W2000666641 cites W2036136248 @default.
• W2000666641 cites W2037341705 @default.
• W2000666641 cites W2045986542 @default.
• W2000666641 cites W2047367436 @default.
• W2000666641 cites W2048512445 @default.
• W2000666641 cites W2055537594 @default.
• W2000666641 cites W2057304101 @default.
• W2000666641 cites W2070273649 @default.
• W2000666641 cites W2070610900 @default.
• W2000666641 cites W2070965152 @default.
• W2000666641 cites W2099802890 @default.
• W2000666641 cites W2100238828 @default.
• W2000666641 cites W2137926032 @default.
• W2000666641 cites W2156594133 @default.
• W2000666641 cites W2160546177 @default.
• W2000666641 cites W2182029699 @default.
• W2000666641 cites W2256298007 @default.
• W2000666641 cites W2274018045 @default.
• W2000666641 cites W2346048525 @default.
• W2000666641 cites W2396413824 @default.
• W2000666641 cites W2411605212 @default.
• W2000666641 cites W2416650544 @default.
• W2000666641 cites W2416991706 @default.
• W2000666641 cites W96550900 @default.
• W2000666641 cites W1916655699 @default.
• W2000666641 doi "https://doi.org/10.1111/j.1469-7793.1997.023bc.x" @default.
• W2000666641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1160091" @default.
• W2000666641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9409469" @default.
• W2000666641 hasPublicationYear "1997" @default.
• W2000666641 type Work @default.
• W2000666641 sameAs 2000666641 @default.
• W2000666641 citedByCount "22" @default.
• W2000666641 countsByYear W20006666412016 @default.
• W2000666641 countsByYear W20006666412019 @default.
• W2000666641 crossrefType "journal-article" @default.
• W2000666641 hasAuthorship W2000666641A5046684721 @default.
• W2000666641 hasAuthorship W2000666641A5053504906 @default.
• W2000666641 hasBestOaLocation W20006666411 @default.
• W2000666641 hasConcept C104317684 @default.
• W2000666641 hasConcept C11960822 @default.
• W2000666641 hasConcept C126322002 @default.
• W2000666641 hasConcept C134018914 @default.
• W2000666641 hasConcept C170493617 @default.
• W2000666641 hasConcept C185592680 @default.
• W2000666641 hasConcept C195794163 @default.
• W2000666641 hasConcept C24998067 @default.
• W2000666641 hasConcept C25274449 @default.
• W2000666641 hasConcept C2777553839 @default.
• W2000666641 hasConcept C2778298627 @default.
• W2000666641 hasConcept C2778428886 @default.
• W2000666641 hasConcept C2779276759 @default.
• W2000666641 hasConcept C42362537 @default.
• W2000666641 hasConcept C55493867 @default.
• W2000666641 hasConcept C62478195 @default.
• W2000666641 hasConcept C71924100 @default.
• W2000666641 hasConcept C85528070 @default.
• W2000666641 hasConcept C86803240 @default.
• W2000666641 hasConcept C97029542 @default.
• W2000666641 hasConceptScore W2000666641C104317684 @default.
• W2000666641 hasConceptScore W2000666641C11960822 @default.
• W2000666641 hasConceptScore W2000666641C126322002 @default.
• W2000666641 hasConceptScore W2000666641C134018914 @default.
• W2000666641 hasConceptScore W2000666641C170493617 @default.
• W2000666641 hasConceptScore W2000666641C185592680 @default.
• W2000666641 hasConceptScore W2000666641C195794163 @default.
• W2000666641 hasConceptScore W2000666641C24998067 @default.
• W2000666641 hasConceptScore W2000666641C25274449 @default.
• W2000666641 hasConceptScore W2000666641C2777553839 @default.
• W2000666641 hasConceptScore W2000666641C2778298627 @default.
• W2000666641 hasConceptScore W2000666641C2778428886 @default.
• W2000666641 hasConceptScore W2000666641C2779276759 @default.
• W2000666641 hasConceptScore W2000666641C42362537 @default.
• W2000666641 hasConceptScore W2000666641C55493867 @default.
• W2000666641 hasConceptScore W2000666641C62478195 @default.
• W2000666641 hasConceptScore W2000666641C71924100 @default.
• W2000666641 hasConceptScore W2000666641C85528070 @default.
• W2000666641 hasConceptScore W2000666641C86803240 @default.
• W2000666641 hasConceptScore W2000666641C97029542 @default.
• W2000666641 hasIssue "1" @default.

• next