Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000669025> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2000669025 endingPage "S326" @default.
- W2000669025 startingPage "S326" @default.
- W2000669025 abstract "To compare dose distribution to volumes of targeted tissues (prostate, seminal vesicles, and pelvic regional nodes at high risk for harboring microscopic disease) and non-targeted tissues (rectum, bladder, small bowel, femurs, and pelvis) in the pelvis with intensity-modulated radiotherapy (IMRT) and forward-planned, double-scattered three-dimensional proton radiotherapy (3DCPRT). An IMRT followed by a prostate 3DCPRT boost (IMRT/3DCPRT), and 3DCPRT plans were created for 5 high-risk prostate cancer patients treated in our Phase II high-risk prostate proton protocol (n = 15 plans). Seventy-eight GE/Gy was prescribed to the prostate and proximal seminal vesicles and 46 GE/Gy was prescribed to the pelvic nodes. Various dosimetric endpoints between the three modalities were compared. Target coverage of the prostate planning target volume (PTV) and nodal PTV was adequate for all three plans. The 3DCPRT plans, when compared to the IMRT and IMRT/3DCPRT plans, reduced the mean dose to the rectum, rectal wall, bladder, bladder wall, small bowel, and pelvis (p < 0.05). When comparing IMRT to IMRT/3DCPRT plans, the IMRT/3DCPRT plans (p < 0.05) reduced the mean dose to all non-target tissues except the small bowel, pelvis, and femurs. The relative benefit of 3DCPRT therapy at reducing the rectum and rectal wall V5 to V70 GE/Gy ranged from 9% to 62% (p < 0.05). For the bladder and bladder wall, the relative benefit for V5 to V45 GE/Gy was 24% to 46% (p < 0.05). The relative benefit for reducing the volume of small bowel irradiated from 5 to 30 GE/Gy in the 3DCPRT ranged from 56% to 62%. 3DCPRT was better than IMRT or IMRT/3DCPRT at sparing non-target tissues. 3DCPRT did not exhibit the typical low-dose “bath” of radiation to the pelvis seen with IMRT. Femoral head doses were higher with 3DCPRT. 3DCPRT significantly reduced the dose to normal tissues in the pelvis while maintaining adequate coverage of the prostate, proximal seminal vesicles, and pelvic lymph nodes when compared to IMRT or IMRT/3DCPRT. When treating the prostate, seminal vesicles, and pelvic lymph nodes in prostate cancer, proton therapy may improve the therapeutic ratio beyond what is possible with IMRT." @default.
- W2000669025 created "2016-06-24" @default.
- W2000669025 creator A5003432320 @default.
- W2000669025 creator A5006151030 @default.
- W2000669025 creator A5023899503 @default.
- W2000669025 creator A5036816456 @default.
- W2000669025 creator A5040117765 @default.
- W2000669025 creator A5072085443 @default.
- W2000669025 creator A5072363037 @default.
- W2000669025 creator A5079400879 @default.
- W2000669025 creator A5089567961 @default.
- W2000669025 date "2008-09-01" @default.
- W2000669025 modified "2023-10-18" @default.
- W2000669025 title "Pelvic Proton Radiotherapy for High-risk Prostate Cancer" @default.
- W2000669025 doi "https://doi.org/10.1016/j.ijrobp.2008.06.1113" @default.
- W2000669025 hasPublicationYear "2008" @default.
- W2000669025 type Work @default.
- W2000669025 sameAs 2000669025 @default.
- W2000669025 citedByCount "0" @default.
- W2000669025 crossrefType "journal-article" @default.
- W2000669025 hasAuthorship W2000669025A5003432320 @default.
- W2000669025 hasAuthorship W2000669025A5006151030 @default.
- W2000669025 hasAuthorship W2000669025A5023899503 @default.
- W2000669025 hasAuthorship W2000669025A5036816456 @default.
- W2000669025 hasAuthorship W2000669025A5040117765 @default.
- W2000669025 hasAuthorship W2000669025A5072085443 @default.
- W2000669025 hasAuthorship W2000669025A5072363037 @default.
- W2000669025 hasAuthorship W2000669025A5079400879 @default.
- W2000669025 hasAuthorship W2000669025A5089567961 @default.
- W2000669025 hasBestOaLocation W20006690251 @default.
- W2000669025 hasConcept C121608353 @default.
- W2000669025 hasConcept C126322002 @default.
- W2000669025 hasConcept C126838900 @default.
- W2000669025 hasConcept C126894567 @default.
- W2000669025 hasConcept C141071460 @default.
- W2000669025 hasConcept C201645570 @default.
- W2000669025 hasConcept C2776235491 @default.
- W2000669025 hasConcept C2778357063 @default.
- W2000669025 hasConcept C2779244869 @default.
- W2000669025 hasConcept C2779762690 @default.
- W2000669025 hasConcept C2780192828 @default.
- W2000669025 hasConcept C2781074409 @default.
- W2000669025 hasConcept C2989005 @default.
- W2000669025 hasConcept C509974204 @default.
- W2000669025 hasConcept C71924100 @default.
- W2000669025 hasConceptScore W2000669025C121608353 @default.
- W2000669025 hasConceptScore W2000669025C126322002 @default.
- W2000669025 hasConceptScore W2000669025C126838900 @default.
- W2000669025 hasConceptScore W2000669025C126894567 @default.
- W2000669025 hasConceptScore W2000669025C141071460 @default.
- W2000669025 hasConceptScore W2000669025C201645570 @default.
- W2000669025 hasConceptScore W2000669025C2776235491 @default.
- W2000669025 hasConceptScore W2000669025C2778357063 @default.
- W2000669025 hasConceptScore W2000669025C2779244869 @default.
- W2000669025 hasConceptScore W2000669025C2779762690 @default.
- W2000669025 hasConceptScore W2000669025C2780192828 @default.
- W2000669025 hasConceptScore W2000669025C2781074409 @default.
- W2000669025 hasConceptScore W2000669025C2989005 @default.
- W2000669025 hasConceptScore W2000669025C509974204 @default.
- W2000669025 hasConceptScore W2000669025C71924100 @default.
- W2000669025 hasIssue "1" @default.
- W2000669025 hasLocation W20006690251 @default.
- W2000669025 hasOpenAccess W2000669025 @default.
- W2000669025 hasPrimaryLocation W20006690251 @default.
- W2000669025 hasRelatedWork W1544952821 @default.
- W2000669025 hasRelatedWork W1987445093 @default.
- W2000669025 hasRelatedWork W2041640911 @default.
- W2000669025 hasRelatedWork W2225495257 @default.
- W2000669025 hasRelatedWork W2274455399 @default.
- W2000669025 hasRelatedWork W3032252569 @default.
- W2000669025 hasRelatedWork W3032687797 @default.
- W2000669025 hasRelatedWork W30869299 @default.
- W2000669025 hasRelatedWork W4243651860 @default.
- W2000669025 hasRelatedWork W4285491790 @default.
- W2000669025 hasVolume "72" @default.
- W2000669025 isParatext "false" @default.
- W2000669025 isRetracted "false" @default.
- W2000669025 magId "2000669025" @default.
- W2000669025 workType "article" @default.