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- W2000671230 abstract "The early principles of the impact of aneuploidy were determined in plants and Drosophila. Here we summarize the classical results and then relate them to more current studies of gene expression in these taxa. As a general rule, aneuploidy is detrimental, even to the point of lethality, compared to changes in the dosage of the whole genome. Gene expression studies demonstrate an analogous relationship, namely that changes in dosage of chromosomes or chromosomal segments will modulate many genes but changes in whole ploidy have much less of an effect. One of the most common trans-acting effects is an inverse response of a gene to the altered dosage of a chromosomal segment. This effect can produce dosage compensation when it occurs for a gene that is also present in the varied region. Some open questions in the field of aneuploidy research are discussed." @default.
- W2000671230 created "2016-06-24" @default.
- W2000671230 creator A5039076657 @default.
- W2000671230 date "2013-04-01" @default.
- W2000671230 modified "2023-10-18" @default.
- W2000671230 title "Aneuploidy in plants and flies: The origin of studies of genomic imbalance" @default.
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- W2000671230 doi "https://doi.org/10.1016/j.semcdb.2013.02.004" @default.
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