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- W2000672344 abstract "Abstract A method is described which enables the controlled assessment of the effects of intranasal drug formulations on rat nasal epithelium. Damage to the nasal mucosa caused by the surfactant laureth-9 (1% w/v) was used as an indicator of the distribution of dose volumes (100, 50 and 20 μl) administered to one side of the nasal cavity. Only the 20 μl volume was retained exclusively in the dosed side. Using this dose volume therefore, the epithelium on the undosed side could be used as control tissue and a direct comparison made between experimental and control tissue in the same section. Errors due to inter-animal variablity and tissue sampling are thus minimised, and the total number of animals required for future studies reduced." @default.
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- W2000672344 date "1991-03-01" @default.
- W2000672344 modified "2023-09-27" @default.
- W2000672344 title "Nasal absorption in the rat. I: A method to demonstrate the histological effects of nasal formulations" @default.
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- W2000672344 doi "https://doi.org/10.1016/0378-5173(91)90159-l" @default.
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