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- W2000672603 abstract "Epstein–Barr virus (EBV) is a gammaherpesvirus with a 172kb genome and many genes encoding enzymes for lytic viral DNA replication. Recent observations indicate that an S-phase-like environment and the activated DNA repair system are required for viral lytic DNA replication. The virally encoded DNA replication-associated enzymes are then expressed in two clusters, suggesting their participation at different stages of replication. Simultaneously, EBV-encoded regulatory proteins may modulate cell-cycle control to enhance virus replication efficiency. The interactions among proteins in the viral replication complex and cellular proteins may either generate structural specificities for replication proteins or stabilize the protein complexes. During infection, EBV has evolved several strategies to overcome the host defense mechanism, such as interfering with innate immunity and withdrawing into a latent state. This review discusses the latest progress in viral control of lytic replication and the interactions among viral lytic replication compartment and cellular machineries. The possible contribution of EBV lytic gene products to human malignancy is also discussed." @default.
- W2000672603 created "2016-06-24" @default.
- W2000672603 creator A5021070959 @default.
- W2000672603 creator A5023229596 @default.
- W2000672603 date "2006-07-01" @default.
- W2000672603 modified "2023-09-24" @default.
- W2000672603 title "Lytic replication of Epstein–Barr virus" @default.
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- W2000672603 cites W1856337372 @default.
- W2000672603 cites W1968017437 @default.
- W2000672603 cites W1973202695 @default.
- W2000672603 cites W1978048533 @default.
- W2000672603 cites W1979859583 @default.
- W2000672603 cites W1983024867 @default.
- W2000672603 cites W1985598849 @default.
- W2000672603 cites W1994898506 @default.
- W2000672603 cites W2000379098 @default.
- W2000672603 cites W2004553600 @default.
- W2000672603 cites W2006155105 @default.
- W2000672603 cites W2011472703 @default.
- W2000672603 cites W2013280412 @default.
- W2000672603 cites W2021073898 @default.
- W2000672603 cites W2036637958 @default.
- W2000672603 cites W2042999246 @default.
- W2000672603 cites W2043801356 @default.
- W2000672603 cites W2046724334 @default.
- W2000672603 cites W2051131460 @default.
- W2000672603 cites W2051541882 @default.
- W2000672603 cites W2054961298 @default.
- W2000672603 cites W2058262035 @default.
- W2000672603 cites W2059007379 @default.
- W2000672603 cites W2059971436 @default.
- W2000672603 cites W2063411863 @default.
- W2000672603 cites W2066158249 @default.
- W2000672603 cites W2068332123 @default.
- W2000672603 cites W2068442698 @default.
- W2000672603 cites W2069650386 @default.
- W2000672603 cites W2075084453 @default.
- W2000672603 cites W2080022600 @default.
- W2000672603 cites W2082559623 @default.
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- W2000672603 cites W2100870126 @default.
- W2000672603 cites W2102755898 @default.
- W2000672603 cites W2103480414 @default.
- W2000672603 cites W2105526885 @default.
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- W2000672603 cites W2140643621 @default.
- W2000672603 cites W2141853045 @default.
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- W2000672603 cites W2145242652 @default.
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- W2000672603 doi "https://doi.org/10.2217/17460794.1.4.435" @default.
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